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10.1126/scitranslmed.aaf6953 http://scihub22266oqcxt.onion/10.1126/scitranslmed.aaf6953 C5434766!5434766!28202777     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Transl+Med 2017 ; 9 (377): ä Nephropedia Template TP {{tp|p=28202777|t=2017. Nodding syndrome may be an autoimmune reaction to the parasitic worm Onchocerca volvulus |pdf=|usr=}}{{28202777}} gab.com Text Nodding syndrome may be an autoimmune reaction to the parasitic worm Onchocerca volvulus JO: Sci Transl Med http://www.kidney.de/pget.php?&tw=1&pmid=28202777 #FOAvip Nodding syndrome is an epileptic disorder of unknown etiology that occurs in children in East Africa. There is an epidemiological association with Onchocerca volvulus, the parasitic worm that causes onchocerciasis (river blindness), but there is limited evidence that the parasite itself is neuroinvasive. We hypothesized that nodding syndrome may be an autoimmune-mediated disease. Using protein chip methodology, we detected autoantibodies to leiomodin-1 more abundantly in patients with nodding syndrome compared to unaffected controls from the same village. Leiomodin-1 autoantibodies were found in both the sera and cerebrospinal fluid of patients with nodding syndrome. Leiomodin-1 was found to be expressed in mature and developing human neurons in vitro and was localized in mouse brain to the CA3 region of the hippocampus, Purkinje cells in the cerebellum, and cortical neurons, structures that also appear to be affected in patients with nodding syndrome. Antibodies targeting leiomodin-1 were neurotoxic in vitro, and leiomodin-1 antibodies purified from patients with nodding syndrome were cross-reactive with O. volvulus antigens. This study provides initial evidence supporting the hypothesis that nodding syndrome is an autoimmune epileptic disorder caused by molecular mimicry with O. volvulus antigens and suggests that patients may benefit from immunomodulatory therapies. Twit Text FOAVip Nodding syndrome may be an autoimmune reaction to the parasitic worm Onchocerca volvulus ????Sci Transl Med http://www.kidney.de/pget.php?&tw=1&pmid=28202777 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28202777 #FOAvip English Wikipedia <ref>{{Cite pmid|28202777}}</ref> Nodding syndrome may be an autoimmune reaction to the parasitic worm Onchocerca volvulus #MMPMID28202777 Johnson TP; Tyagi R; Lee PR; Lee MH; Johnson KR; Kowalak J; Elkahloun A; Medynets M; Hategan A; Kubofcik J; Sejvar J; Ratto J; Bunga S; Makumbi I; Aceng JR; Nutman TB; Dowell SF; Nath A Sci Transl Med 2017[Feb]; 9 (377): ä PMID28202777show ga Nodding syndrome is an epileptic disorder of unknown etiology that occurs in children in East Africa. There is an epidemiological association with Onchocerca volvulus, the parasitic worm that causes onchocerciasis (river blindness), but there is limited evidence that the parasite itself is neuroinvasive. We hypothesized that nodding syndrome may be an autoimmune-mediated disease. Using protein chip methodology, we detected autoantibodies to leiomodin-1 more abundantly in patients with nodding syndrome compared to unaffected controls from the same village. Leiomodin-1 autoantibodies were found in both the sera and cerebrospinal fluid of patients with nodding syndrome. Leiomodin-1 was found to be expressed in mature and developing human neurons in vitro and was localized in mouse brain to the CA3 region of the hippocampus, Purkinje cells in the cerebellum, and cortical neurons, structures that also appear to be affected in patients with nodding syndrome. Antibodies targeting leiomodin-1 were neurotoxic in vitro, and leiomodin-1 antibodies purified from patients with nodding syndrome were cross-reactive with O. volvulus antigens. This study provides initial evidence supporting the hypothesis that nodding syndrome is an autoimmune epileptic disorder caused by molecular mimicry with O. volvulus antigens and suggests that patients may benefit from immunomodulatory therapies. äNodding syndrome may be an autoimmune reaction to the parasitic worm O(epmc).pdf DeepDyve Pubget Overpricing