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10.1186/s13048-017-0332-5

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suck abstract from ncbi


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pmid28511712
      J+Ovarian+Res 2017 ; 10 (1 ): 35
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  • What we learned from extended culture of rejected day-3 cleavage stage embryos: a prospective cohort study #MMPMID28511712
  • Hershko Klement A ; Ovadia M ; Wiser A ; Berkovitz A ; Shavit T ; Nemerovsky L ; Ghetler Y ; Cohen I ; Shulman A
  • J Ovarian Res 2017[May]; 10 (1 ): 35 PMID28511712 show ga
  • BACKGROUND: To test whether poor quality day-3 embryos can undergo successful blastulation and implantation. METHODS: A prospective cohort study was conducted. Whether or not a good quality embryo was transferred on day-3, poor quality (rejected) embryos were further cultured and followed. The clinical outcome of each embryo was assessed. RESULTS: A total of 694 rejected embryos (from 205 patients) were included, with a blastulation rate of 21.2% (147 embryos) compared to 64.2% general blastulation rate reported by our laboratory (P < 0.01). In a multivariate logistic regression model, only their grade on day-3 significantly affected blastulation (P = 0.01). A total of 97 embryos attained eligibility for fresh transfer or cryopreservation, only 6 of which resulted from a day-3 embryo scored < 2. Of these, 52 were transferred, resulting in 21 pregnancies (16 clinical and 5 chemical). In summary, 694 cultured embryos yielded 16 clinical pregnancies; a 2.3% clinical pregnancy rate. CONCLUSIONS: Low score day-3 embryos can result in successful blastulation and clinical pregnancies. However, the normal blastulation rate is poor.
  • |Adult [MESH]
  • |Blastocyst/*physiology [MESH]
  • |Cleavage Stage, Ovum/*physiology [MESH]
  • |Cryopreservation [MESH]
  • |Embryo Culture Techniques [MESH]
  • |Embryo Implantation/*physiology [MESH]
  • |Embryo Transfer/methods [MESH]
  • |Female [MESH]
  • |Humans [MESH]
  • |Maternal Age [MESH]
  • |Pregnancy [MESH]
  • |Pregnancy Rate [MESH]
  • |Prognosis [MESH]


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