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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Ovarian+Res
2017 ; 10
(1
): 35
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What we learned from extended culture of rejected day-3 cleavage stage embryos:
a prospective cohort study
#MMPMID28511712
Hershko Klement A
; Ovadia M
; Wiser A
; Berkovitz A
; Shavit T
; Nemerovsky L
; Ghetler Y
; Cohen I
; Shulman A
J Ovarian Res
2017[May]; 10
(1
): 35
PMID28511712
show ga
BACKGROUND: To test whether poor quality day-3 embryos can undergo successful
blastulation and implantation. METHODS: A prospective cohort study was conducted.
Whether or not a good quality embryo was transferred on day-3, poor quality
(rejected) embryos were further cultured and followed. The clinical outcome of
each embryo was assessed. RESULTS: A total of 694 rejected embryos (from 205
patients) were included, with a blastulation rate of 21.2% (147 embryos) compared
to 64.2% general blastulation rate reported by our laboratory (P < 0.01). In a
multivariate logistic regression model, only their grade on day-3 significantly
affected blastulation (P = 0.01). A total of 97 embryos attained eligibility for
fresh transfer or cryopreservation, only 6 of which resulted from a day-3 embryo
scored < 2. Of these, 52 were transferred, resulting in 21 pregnancies (16
clinical and 5 chemical). In summary, 694 cultured embryos yielded 16 clinical
pregnancies; a 2.3% clinical pregnancy rate. CONCLUSIONS: Low score day-3 embryos
can result in successful blastulation and clinical pregnancies. However, the
normal blastulation rate is poor.