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Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Biomed+Res+Int 2017 ; 2017 (ä): ä Nephropedia Template TP
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Serum Sclerostin Levels in Patients with Ankylosing Spondylitis and Rheumatoid Arthritis: A Systematic Review and Meta-Analysis #MMPMID28553652
Shi J; Ying H; Du J; Shen B
Biomed Res Int 2017[]; 2017 (ä): ä PMID28553652show ga
Objective. Current studies of serum sclerostin levels in AS and RA patients are inconsistent. This meta-analysis was performed to identify the association of serum sclerostin level with AS and RA patients. Methods. Embase, PubMed, MEDLINE, and Cochrane Library databases (up to 25 January 2017) were used to collect all relevant published articles. Studies were pooled and standard mean difference (SMD) with 95% confidence interval (CI) was calculated. All data analyses were performed using RevMan 5.3. Results. Totally eight studies of AS including 420 AS patients and 317 healthy controls (HC) and three studies of RA including 145?RA patients and 127?HC were finally included in this meta-analysis. The results revealed that the serum sclerostin levels in both AS patients (SMD = ?0.14; 95% CI = [?0.39,0.11]; P = 0.28) and RA patients (SMD = ?0.10; 95% CI = [?0.34,0.15]; P = 0.43) were not significantly different from those in HC. Conclusion. The difference of serum sclerostin levels in AS and RA patients was not significantly different from HC, indicating that the sclerostin may not associate with the development of AS and RA.