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2017 ; 2017
(ä): 9295313
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Serum Sclerostin Levels in Patients with Ankylosing Spondylitis and Rheumatoid
Arthritis: A Systematic Review and Meta-Analysis
#MMPMID28553652
Shi J
; Ying H
; Du J
; Shen B
Biomed Res Int
2017[]; 2017
(ä): 9295313
PMID28553652
show ga
Objective. Current studies of serum sclerostin levels in AS and RA patients are
inconsistent. This meta-analysis was performed to identify the association of
serum sclerostin level with AS and RA patients. Methods. Embase, PubMed, MEDLINE,
and Cochrane Library databases (up to 25 January 2017) were used to collect all
relevant published articles. Studies were pooled and standard mean difference
(SMD) with 95% confidence interval (CI) was calculated. All data analyses were
performed using RevMan 5.3. Results. Totally eight studies of AS including 420 AS
patients and 317 healthy controls (HC) and three studies of RA including 145?RA
patients and 127?HC were finally included in this meta-analysis. The results
revealed that the serum sclerostin levels in both AS patients (SMD = -0.14; 95%
CI = [-0.39,0.11]; P = 0.28) and RA patients (SMD = -0.10; 95% CI = [-0.34,0.15];
P = 0.43) were not significantly different from those in HC. Conclusion. The
difference of serum sclerostin levels in AS and RA patients was not significantly
different from HC, indicating that the sclerostin may not associate with the
development of AS and RA.