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10.3174/ajnr.A5129 http://scihub22266oqcxt.onion/10.3174/ajnr.A5129 C5433915!5433915!28341719     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       AJNR+Am+J+Neuroradiol 2017 ; 38 (5): 862-7 Nephropedia Template TP {{tp|p=28341719|t=2017. Brain Perivascular Spaces as Biomarkers of Vascular Risk: Results from the Northern Manhattan Study |pdf=|usr=}}{{28341719}} gab.com Text Brain Perivascular Spaces as Biomarkers of Vascular Risk: Results from the Northern Manhattan Study JO: AJNR Am J Neuroradiol http://www.kidney.de/pget.php?&tw=1&pmid=28341719 #FOAvip BACKGROUND AND PURPOSE:: Dilated perivascular spaces in the brain are associated with greater arterial pulsatility. We hypothesized that perivascular spaces identify individuals at higher risk for systemic and cerebral vascular events. MATERIALS AND METHODS:: Stroke-free participants in the population-based Northern Manhattan Study had brain MR imaging performed and were followed for myocardial infarction, any stroke, and death. Imaging analyses distinguished perivascular spaces from lesions presumably ischemic. Perivascular spaces were further subdivided into lesions with diameters of ?3 mm (small perivascular spaces) and >3 mm (large perivascular spaces). We calculated relative rates of events with Poisson models and hazard ratios with Cox proportional models. RESULTS:: The Northern Manhattan Study participants who had MR imaging data available for review (n = 1228; 59% women, 65% Hispanic; mean age, 71 ± 9 years) were followed for an average of 9 ± 2 years. Participants in the highest tertile of the small perivascular space score had a higher relative rate of all deaths (relative rate, 1.38; 95% CI, 1.01?1.91), vascular death (relative rate, 1.87; 95% CI, 1.12?3.14), myocardial infarction (relative rate, 2.08; 95% CI, 1.01?4.31), any stroke (relative rate, 1.79; 95% CI, 1.03?3.11), and any vascular event (relative rate, 1.74; 95% CI, 1.18?2.56). After we adjusted for confounders, there was a higher risk of vascular death (hazard ratio, 1.06; 95% CI, 1.01?1.11), myocardial infarction (hazard ratio, 2.22; 95% CI, 1.12?4.42), and any vascular event (hazard ratio, 1.04; 95% CI, 1.01?1.08) with higher small perivascular space scores. CONCLUSIONS:: In this multiethnic, population-based study, participants with a high burden of small perivascular spaces had increased risk of vascular events. By gaining pathophysiologic insight into the mechanism of perivascular space dilation, we may be able to propose novel therapies to better prevent vascular disorders in the population. Twit Text FOAVip Brain Perivascular Spaces as Biomarkers of Vascular Risk: Results from the Northern Manhattan Study ????AJNR Am J Neuroradiol http://www.kidney.de/pget.php?&tw=1&pmid=28341719 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28341719 #FOAvip English Wikipedia <ref>{{Cite pmid|28341719}}</ref> Brain Perivascular Spaces as Biomarkers of Vascular Risk: Results from the Northern Manhattan Study #MMPMID28341719 Gutierrez J; Elkind M; Dong C; Di Tullio M; Rundek T; Sacco R; Wright C AJNR Am J Neuroradiol 2017[May]; 38 (5): 862-7 PMID28341719show ga BACKGROUND AND PURPOSE:: Dilated perivascular spaces in the brain are associated with greater arterial pulsatility. We hypothesized that perivascular spaces identify individuals at higher risk for systemic and cerebral vascular events. MATERIALS AND METHODS:: Stroke-free participants in the population-based Northern Manhattan Study had brain MR imaging performed and were followed for myocardial infarction, any stroke, and death. Imaging analyses distinguished perivascular spaces from lesions presumably ischemic. Perivascular spaces were further subdivided into lesions with diameters of ?3 mm (small perivascular spaces) and >3 mm (large perivascular spaces). We calculated relative rates of events with Poisson models and hazard ratios with Cox proportional models. RESULTS:: The Northern Manhattan Study participants who had MR imaging data available for review (n = 1228; 59% women, 65% Hispanic; mean age, 71 ± 9 years) were followed for an average of 9 ± 2 years. Participants in the highest tertile of the small perivascular space score had a higher relative rate of all deaths (relative rate, 1.38; 95% CI, 1.01?1.91), vascular death (relative rate, 1.87; 95% CI, 1.12?3.14), myocardial infarction (relative rate, 2.08; 95% CI, 1.01?4.31), any stroke (relative rate, 1.79; 95% CI, 1.03?3.11), and any vascular event (relative rate, 1.74; 95% CI, 1.18?2.56). After we adjusted for confounders, there was a higher risk of vascular death (hazard ratio, 1.06; 95% CI, 1.01?1.11), myocardial infarction (hazard ratio, 2.22; 95% CI, 1.12?4.42), and any vascular event (hazard ratio, 1.04; 95% CI, 1.01?1.08) with higher small perivascular space scores. CONCLUSIONS:: In this multiethnic, population-based study, participants with a high burden of small perivascular spaces had increased risk of vascular events. By gaining pathophysiologic insight into the mechanism of perivascular space dilation, we may be able to propose novel therapies to better prevent vascular disorders in the population. äBrain Perivascular Spaces as Biomarkers of Vascular Risk: Results from(epmc).pdf DeepDyve Pubget Overpricing