Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1016/j.jid.2016.11.037 http://scihub22266oqcxt.onion/10.1016/j.jid.2016.11.037 C5433864!5433864!28012718     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Invest+Dermatol 2017 ; 137 (5): 1042-50 Nephropedia Template TP {{tp|p=28012718|t=2017. Skin-resident effector memory CD8+CD28? T cells exhibit a pro-fibrotic phenotype in patients with systemic sclerosis |pdf=|usr=}}{{28012718}} gab.com Text Skin-resident effector memory CD8+CD28 T cells exhibit a pro-fibrotic phenotype in patients with systemic sclerosis JO: J Invest Dermatol http://www.kidney.de/pget.php?&tw=1&pmid=28012718 #FOAvip Loss of CD28 expression by CD8+ T cells occurs with age and during chronic inflammatory conditions. CD8+CD28? T cells are a heterogeneous cell subpopulation whose function ranges from immunosuppressive to effector. Here we analyzed the role of CD8+CD28? T cells in the pathogenesis of systemic sclerosis (SSc), a connective tissue disorder characterized by autoimmunity, vasculopathy and extensive cutaneous and visceral fibrosis. We show that the frequency of CD8+CD28? T cells is increased in the blood and affected skin of SSc patients, independent of patient age, and correlates with the extent of skin fibrosis. We found that the majority of skin-tropic CD8+CD28? T cells are resident in the skin lesions of patients in the early stage of the disease, exhibit an effector memory phenotype and present a strong cytolytic activity ex vivo. Skin-resident and circulating SSc CD8+CD28? T cells produce high levels of the pro-fibrotic cytokine IL-13, which induces collagen production by normal and SSc dermal fibroblasts. Thus, our findings indicate that CD8+CD28? T cells represent a pathogenic T-cell subset in SSc and likely play a critical role in the early stage of SSc skin disease. Twit Text FOAVip Skin-resident effector memory CD8+CD28 T cells exhibit a pro-fibrotic phenotype in patients with systemic sclerosis ????J Invest Dermatol http://www.kidney.de/pget.php?&tw=1&pmid=28012718 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28012718 #FOAvip English Wikipedia <ref>{{Cite pmid|28012718}}</ref> Skin-resident effector memory CD8+CD28? T cells exhibit a pro-fibrotic phenotype in patients with systemic sclerosis #MMPMID28012718 Li G; Larregina AT; Domsic RT; Stolz DB; Medsger TA; Lafyatis R; Fuschiotti P J Invest Dermatol 2017[May]; 137 (5): 1042-50 PMID28012718show ga Loss of CD28 expression by CD8+ T cells occurs with age and during chronic inflammatory conditions. CD8+CD28? T cells are a heterogeneous cell subpopulation whose function ranges from immunosuppressive to effector. Here we analyzed the role of CD8+CD28? T cells in the pathogenesis of systemic sclerosis (SSc), a connective tissue disorder characterized by autoimmunity, vasculopathy and extensive cutaneous and visceral fibrosis. We show that the frequency of CD8+CD28? T cells is increased in the blood and affected skin of SSc patients, independent of patient age, and correlates with the extent of skin fibrosis. We found that the majority of skin-tropic CD8+CD28? T cells are resident in the skin lesions of patients in the early stage of the disease, exhibit an effector memory phenotype and present a strong cytolytic activity ex vivo. Skin-resident and circulating SSc CD8+CD28? T cells produce high levels of the pro-fibrotic cytokine IL-13, which induces collagen production by normal and SSc dermal fibroblasts. Thus, our findings indicate that CD8+CD28? T cells represent a pathogenic T-cell subset in SSc and likely play a critical role in the early stage of SSc skin disease. äSkin-resident effector memory CD8+CD28? T cells exhibit a pro-fibrotic(epmc).pdf DeepDyve Pubget Overpricing