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10.1016/j.jid.2016.11.037 http://scihub22266oqcxt.onion/10.1016/j.jid.2016.11.037 C5433864!5433864 !28012718     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28012718 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Invest+Dermatol 2017 ; 137 (5 ): 1042-1050 Nephropedia Template TP {{tp|p=28012718 |t=2017. Skin-Resident Effector Memory CD8(+)CD28(-) T Cells Exhibit a Profibrotic Phenotype in Patients with Systemic Sclerosis |pdf=|usr=}}{{28012718 }} gab.com Text Skin-Resident Effector Memory CD8(+)CD28(-) T Cells Exhibit a Profibrotic Phenotype in Patients with Systemic Sclerosis JO: J Invest Dermatol http://www.kidney.de/pget.php?&tw=1&pmid=28012718 #FOAvip Loss of CD28 expression by CD8(+) T cells occurs with age and during chronic inflammatory conditions. CD8(+)CD28(-) T cells are a heterogeneous cell subpopulation whose function ranges from immunosuppressive to effector. Here we analyzed the role of CD8(+)CD28(-) T cells in the pathogenesis of systemic sclerosis (SSc), a connective tissue disorder characterized by autoimmunity, vasculopathy, and extensive cutaneous and visceral fibrosis. We show that the frequency of CD8(+)CD28(-) T cells is increased in the blood and affected skin of SSc patients, independent of patient age, and correlates with the extent of skin fibrosis. We found that most skin-tropic CD8(+)CD28(-) T cells are resident in the skin lesions of patients in the early stage of the disease, exhibit an effector memory phenotype, and present a strong cytolytic activity ex vivo. Skin-resident and circulating SSc CD8(+)CD28(-) T cells produce high levels of the profibrotic cytokine IL-13, which induces collagen production by normal and SSc dermal fibroblasts. Thus, our findings indicate that CD8(+)CD28(-) T cells represent a pathogenic T-cell subset in SSc and likely play a critical role in the early stage of SSc skin disease. Twit Text FOAVip Skin-Resident Effector Memory CD8(+)CD28(-) T Cells Exhibit a Profibrotic Phenotype in Patients with Systemic Sclerosis ????J Invest Dermatol http://www.kidney.de/pget.php?&tw=1&pmid=28012718 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28012718 #FOAvip English Wikipedia <ref>{{Cite pmid|28012718 }}</ref> Skin-Resident Effector Memory CD8(+)CD28(-) T Cells Exhibit a Profibrotic Phenotype in Patients with Systemic Sclerosis #MMPMID28012718 Li G ; Larregina AT ; Domsic RT ; Stolz DB ; Medsger TA Jr ; Lafyatis R ; Fuschiotti P J Invest Dermatol 2017[May]; 137 (5 ): 1042-1050 PMID28012718 show ga Loss of CD28 expression by CD8(+) T cells occurs with age and during chronic inflammatory conditions. CD8(+)CD28(-) T cells are a heterogeneous cell subpopulation whose function ranges from immunosuppressive to effector. Here we analyzed the role of CD8(+)CD28(-) T cells in the pathogenesis of systemic sclerosis (SSc), a connective tissue disorder characterized by autoimmunity, vasculopathy, and extensive cutaneous and visceral fibrosis. We show that the frequency of CD8(+)CD28(-) T cells is increased in the blood and affected skin of SSc patients, independent of patient age, and correlates with the extent of skin fibrosis. We found that most skin-tropic CD8(+)CD28(-) T cells are resident in the skin lesions of patients in the early stage of the disease, exhibit an effector memory phenotype, and present a strong cytolytic activity ex vivo. Skin-resident and circulating SSc CD8(+)CD28(-) T cells produce high levels of the profibrotic cytokine IL-13, which induces collagen production by normal and SSc dermal fibroblasts. Thus, our findings indicate that CD8(+)CD28(-) T cells represent a pathogenic T-cell subset in SSc and likely play a critical role in the early stage of SSc skin disease. |Adult [MESH] |Aged [MESH] |CD28 Antigens/*immunology [MESH] |CD8-Positive T-Lymphocytes/*immunology [MESH] |Case-Control Studies [MESH] |Collagen/metabolism [MESH] |Female [MESH] |Fibrosis [MESH] |Humans [MESH] |Interleukin-13/*metabolism [MESH] |Male [MESH] |Middle Aged [MESH] |Phenotype [MESH] |Scleroderma, Systemic/immunology/*physiopathology [MESH] |Skin/immunology/*pathology [MESH]Skin-Resident Effector Memory CD8(+)CD28(-) T Cells Exhibit a Profibro(epmc).pdf DeepDyve Pubget Overpricing