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10.7554/eLife.23130 http://scihub22266oqcxt.onion/10.7554/eLife.23130 C5433852!5433852!28510528     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       eLife 2017 ; 6 (ä): ä Nephropedia Template TP {{tp|p=28510528|t=2017. Identification of octopaminergic neurons that modulate sleep suppression by male sex drive |pdf=|usr=}}{{28510528}} gab.com Text Identification of octopaminergic neurons that modulate sleep suppression by male sex drive JO: eLife http://www.kidney.de/pget.php?&tw=1&pmid=28510528 #FOAvip Molecular and circuit mechanisms for balancing competing drives are not well understood. While circadian and homeostatic mechanisms generally ensure sufficient sleep at night, other pressing needs can overcome sleep drive. Here, we demonstrate that the balance between sleep and sex drives determines whether male flies sleep or court, and identify a subset of octopaminergic neurons (MS1) that regulate sleep specifically in males. When MS1 neurons are activated, isolated males sleep less, and when MS1 neurons are silenced, the normal male sleep suppression in female presence is attenuated and mating behavior is impaired. MS1 neurons do not express the sexually dimorphic FRUITLESS (FRU) transcription factor, but form male-specific contacts with FRU-expressing neurons; calcium imaging experiments reveal bidirectional functional connectivity between MS1 and FRU neurons. We propose octopaminergic MS1 neurons interact with the FRU network to mediate sleep suppression by male sex drive.DOI:http://dx.doi.org/10.7554/eLife.23130.001 Twit Text FOAVip Identification of octopaminergic neurons that modulate sleep suppression by male sex drive ????eLife http://www.kidney.de/pget.php?&tw=1&pmid=28510528 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28510528 #FOAvip English Wikipedia <ref>{{Cite pmid|28510528}}</ref> Identification of octopaminergic neurons that modulate sleep suppression by male sex drive #MMPMID28510528 Machado DR; Afonso DJ; Kenny AR; Öztürk-Çolak A; Moscato EH; Mainwaring B; Kayser M; Koh K eLife 2017[]; 6 (ä): ä PMID28510528show ga Molecular and circuit mechanisms for balancing competing drives are not well understood. While circadian and homeostatic mechanisms generally ensure sufficient sleep at night, other pressing needs can overcome sleep drive. Here, we demonstrate that the balance between sleep and sex drives determines whether male flies sleep or court, and identify a subset of octopaminergic neurons (MS1) that regulate sleep specifically in males. When MS1 neurons are activated, isolated males sleep less, and when MS1 neurons are silenced, the normal male sleep suppression in female presence is attenuated and mating behavior is impaired. MS1 neurons do not express the sexually dimorphic FRUITLESS (FRU) transcription factor, but form male-specific contacts with FRU-expressing neurons; calcium imaging experiments reveal bidirectional functional connectivity between MS1 and FRU neurons. We propose octopaminergic MS1 neurons interact with the FRU network to mediate sleep suppression by male sex drive.DOI:http://dx.doi.org/10.7554/eLife.23130.001 äIdentification of octopaminergic neurons that modulate sleep suppressi(epmc).pdf DeepDyve Pubget Overpricing