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10.7554/eLife.24623 http://scihub22266oqcxt.onion/10.7554/eLife.24623 C5433844!5433844!28508748     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       eLife 2017 ; 6 (ä): ä Nephropedia Template TP {{tp|p=28508748|t=2017. Macrophages are necessary for epimorphic regeneration in African spiny mice |pdf=|usr=}}{{28508748}} gab.com Text Macrophages are necessary for epimorphic regeneration in African spiny mice JO: eLife http://www.kidney.de/pget.php?&tw=1&pmid=28508748 #FOAvip How the immune system affects tissue regeneration is not well understood. In this study, we used an emerging mammalian model of epimorphic regeneration, the African spiny mouse, to examine cell-based inflammation and tested the hypothesis that macrophages are necessary for regeneration. By directly comparing inflammatory cell activation in a 4 mm ear injury during regeneration (Acomys cahirinus) and scarring (Mus musculus), we found that both species exhibited an acute inflammatory response, with scarring characterized by stronger myeloperoxidase activity. In contrast, ROS production was stronger and more persistent during regeneration. By depleting macrophages during injury, we demonstrate a functional requirement for these cells to stimulate regeneration. Importantly, the spatial distribution of activated macrophage subtypes was unique during regeneration with pro-inflammatory macrophages failing to infiltrate the regeneration blastema. Together, our results demonstrate an essential role for inflammatory cells to regulate a regenerative response.DOI:http://dx.doi.org/10.7554/eLife.24623.001 Twit Text FOAVip Macrophages are necessary for epimorphic regeneration in African spiny mice ????eLife http://www.kidney.de/pget.php?&tw=1&pmid=28508748 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28508748 #FOAvip English Wikipedia <ref>{{Cite pmid|28508748}}</ref> Macrophages are necessary for epimorphic regeneration in African spiny mice #MMPMID28508748 Simkin J; Gawriluk TR; Gensel JC; Seifert AW eLife 2017[]; 6 (ä): ä PMID28508748show ga How the immune system affects tissue regeneration is not well understood. In this study, we used an emerging mammalian model of epimorphic regeneration, the African spiny mouse, to examine cell-based inflammation and tested the hypothesis that macrophages are necessary for regeneration. By directly comparing inflammatory cell activation in a 4 mm ear injury during regeneration (Acomys cahirinus) and scarring (Mus musculus), we found that both species exhibited an acute inflammatory response, with scarring characterized by stronger myeloperoxidase activity. In contrast, ROS production was stronger and more persistent during regeneration. By depleting macrophages during injury, we demonstrate a functional requirement for these cells to stimulate regeneration. Importantly, the spatial distribution of activated macrophage subtypes was unique during regeneration with pro-inflammatory macrophages failing to infiltrate the regeneration blastema. Together, our results demonstrate an essential role for inflammatory cells to regulate a regenerative response.DOI:http://dx.doi.org/10.7554/eLife.24623.001 äMacrophages are necessary for epimorphic regeneration in African spiny(epmc).pdf DeepDyve Pubget Overpricing