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10.1186/s40425-017-0244-3

http://scihub22266oqcxt.onion/10.1186/s40425-017-0244-3
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C5433173!5433173!28515941
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suck abstract from ncbi


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pmid28515941      J+Immunother+Cancer 2017 ; 5 (ä): ä
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  • Tissue-resident lymphocytes: sentinel of the transformed tissue #MMPMID28515941
  • Dadi S; Li MO
  • J Immunother Cancer 2017[]; 5 (ä): ä PMID28515941show ga
  • Tumor cells can be detected and cleared by lymphocytes in a process termed cancer immunosurveillance. However, the contributing cell types had not been fully characterized. Using oncogene-induced murine models of epithelial cancer, a recent study showed that cell transformation triggers expansion of tissue-resident lymphocytes derived from innate, T cell receptor (TCR) ?? and TCR?? lineages. These type-1-like innate lymphoid cells (ILC1ls) and type 1 innate-like T cells (ILTC1s) share a gene expression program distinct from those of conventional lymphocytes, and exhibit cytolytic activities against tumor cells. Further deciphering such a tumor-elicited immunosurveillance mechanism may 1 day be harnessed for novel cancer immunotherapy.
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