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2017 ; 18
(1
): 219
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gab.com Text
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The INVEST project: investigating the use of evidence synthesis in the design and
analysis of clinical trials
#MMPMID28506284
Clayton GL
; Smith IL
; Higgins JPT
; Mihaylova B
; Thorpe B
; Cicero R
; Lokuge K
; Forman JR
; Tierney JF
; White IR
; Sharples LD
; Jones HE
Trials
2017[May]; 18
(1
): 219
PMID28506284
show ga
BACKGROUND: When designing and analysing clinical trials, using previous relevant
information, perhaps in the form of evidence syntheses, can reduce research
waste. We conducted the INVEST (INVestigating the use of Evidence Synthesis in
the design and analysis of clinical Trials) survey to summarise the current use
of evidence synthesis in trial design and analysis, to capture opinions of
trialists and methodologists on such use, and to understand any barriers.
METHODS: Our sampling frame was all delegates attending the International
Clinical Trials Methodology Conference in November 2015. Respondents were asked
to indicate (1) their views on the use of evidence synthesis in trial design and
analysis, (2) their own use during the past 10 years and (3) the three greatest
barriers to use in practice. RESULTS: Of approximately 638 attendees of the
conference, 106 (17%) completed the survey, half of whom were statisticians.
Support was generally high for using a description of previous evidence, a
systematic review or a meta-analysis in trial design. Generally, respondents did
not seem to be using evidence syntheses as often as they felt they should. For
example, only 50% (42/84 relevant respondents) had used a meta-analysis to inform
whether a trial is needed compared with 74% (62/84) indicating that this is
desirable. Only 6% (5/81 relevant respondents) had used a value of information
analysis to inform sample size calculations versus 22% (18/81) indicating support
for this. Surprisingly large numbers of participants indicated support for, and
previous use of, evidence syntheses in trial analysis. For example, 79% (79/100)
of respondents indicated that external information about the treatment effect
should be used to inform aspects of the analysis. The greatest perceived barrier
to using evidence synthesis methods in trial design or analysis was time
constraints, followed by a belief that the new trial was the first in the area.
CONCLUSIONS: Evidence syntheses can be resource-intensive, but their use in
informing the design, conduct and analysis of clinical trials is widely
considered desirable. We advocate additional research, training and investment in
resources dedicated to ways in which evidence syntheses can be undertaken more
efficiently, offering the potential for cost savings in the long term.
|*Research Design/statistics & numerical data
[MESH]
|*Research Personnel/statistics & numerical data
[MESH]
|Bayes Theorem
[MESH]
|Biostatistics/*methods
[MESH]
|Clinical Trials as Topic/*methods/statistics & numerical data
[MESH]
|Congresses as Topic
[MESH]
|Data Interpretation, Statistical
[MESH]
|Evidence-Based Medicine/*methods/statistics & numerical data
[MESH]
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