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2017 ; 8
(ä): 296
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Innovative Perspective: Gadolinium-Free Magnetic Resonance Imaging in Long-Term
Follow-Up after Kidney Transplantation
#MMPMID28559850
van Eijs MJM
; van Zuilen AD
; de Boer A
; Froeling M
; Nguyen TQ
; Joles JA
; Leiner T
; Verhaar MC
Front Physiol
2017[]; 8
(ä): 296
PMID28559850
show ga
Since the mid-1980s magnetic resonance imaging (MRI) has been investigated as a
non- or minimally invasive tool to probe kidney allograft function. Despite this
long-standing interest, MRI still plays a subordinate role in daily practice of
transplantation nephrology. With the introduction of new functional MRI
techniques, administration of exogenous gadolinium-based contrast agents has
often become unnecessary and true non-invasive assessment of allograft function
has become possible. This raises the question why application of MRI in the
follow-up of kidney transplantation remains restricted, despite promising
results. Current literature on kidney allograft MRI is mainly focused on
assessment of (sub) acute kidney injury after transplantation. The aim of this
review is to survey whether MRI can provide valuable diagnostic information
beyond 1 year after kidney transplantation from a mechanistic point of view. The
driving force behind chronic allograft nephropathy is believed to be chronic
hypoxia. Based on this, techniques that visualize kidney perfusion and
oxygenation, scarring, and parenchymal inflammation deserve special interest. We
propose that functional MRI mechanistically provides tools for diagnostic work-up
in long-term follow-up of kidney allografts.