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10.18632/oncotarget.15175

http://scihub22266oqcxt.onion/10.18632/oncotarget.15175
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C5432359!5432359!28187439
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suck abstract from ncbi

pmid28187439      Oncotarget 2017 ; 8 (16): 27582-92
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  • Long non-coding RNA in glioma: signaling pathways #MMPMID28187439
  • Shi J; Dong B; Cao J; Mao Y; Guan W; Peng Y; Wang S
  • Oncotarget 2017[Apr]; 8 (16): 27582-92 PMID28187439show ga
  • Glioma is regarded as the most prevalent malignant carcinoma of the central nervous system. Thus, the development of new therapeutic strategies targeting glioma is of significant clinical importance. Long non-coding RNAs (lncRNAs) are functional RNA molecules without a protein-coding function and are reportedly involved in the initiation and progression of glioma. Dysregulation of lncRNAs in glioma is due to activation of several signaling pathways, such as the BRD4-HOTAIR-?-catenin/PDCD4, p53-Hif-H19/IGF2 and CRNDE/mTOR pathways. Furthermore, microRNAs (miRNAs) such as miR-675 also interact with lncRNAs in glioma. Thus, exploring the mechanisms by which lncRNA control processes will be instrumental for devising new effective therapies against glioma.
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