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10.18632/oncotarget.15677 http://scihub22266oqcxt.onion/10.18632/oncotarget.15677 C5432326!5432326!28460443     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncotarget 2017 ; 8 (16): 27166-76 Nephropedia Template TP {{tp|p=28460443|t=2017. Sphingosine-1-phosphate promotes ovarian cancer cell proliferation by disrupting Hippo signaling |pdf=|usr=}}{{28460443}} gab.com Text Sphingosine-1-phosphate promotes ovarian cancer cell proliferation by disrupting Hippo signaling JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28460443 #FOAvip Epithelial ovarian carcinomas account for more than 90% of human ovarian cancers and have become the primary cause of death for gynecological malignancies. Unlimited cell proliferation and resistance to cell apoptosis contribute to the development of ovarian cancers. However, the underlying mechanisms involved in these processes in epithelial ovarian carcinomas are yet poorly understood. In the present study, we examined the Hippo signaling gene expression and investigated the effects of Sphingosine 1-phosphate (S1P) on cell proliferation and the underlying mechanisms in human ovarian cancer cell lines, OVCAR3 and SKOV3. Our results demonstrate that S1P disrupts Hippo signaling by reducing YAP phosphorylation and increasing the expression of CCN1 and CCN2 in both ovarian cancer cells. Furthermore, the increase in CCN1/CCN2 expression contributes to the S1P-induced increase in cancer cell proliferation. Twit Text FOAVip Sphingosine-1-phosphate promotes ovarian cancer cell proliferation by disrupting Hippo signaling ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28460443 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28460443 #FOAvip English Wikipedia <ref>{{Cite pmid|28460443}}</ref> Sphingosine-1-phosphate promotes ovarian cancer cell proliferation by disrupting Hippo signaling #MMPMID28460443 Fan Q; Cheng Y; Chang HM; Deguchi M; Hsueh AJ; Leung PC Oncotarget 2017[Apr]; 8 (16): 27166-76 PMID28460443show ga Epithelial ovarian carcinomas account for more than 90% of human ovarian cancers and have become the primary cause of death for gynecological malignancies. Unlimited cell proliferation and resistance to cell apoptosis contribute to the development of ovarian cancers. However, the underlying mechanisms involved in these processes in epithelial ovarian carcinomas are yet poorly understood. In the present study, we examined the Hippo signaling gene expression and investigated the effects of Sphingosine 1-phosphate (S1P) on cell proliferation and the underlying mechanisms in human ovarian cancer cell lines, OVCAR3 and SKOV3. Our results demonstrate that S1P disrupts Hippo signaling by reducing YAP phosphorylation and increasing the expression of CCN1 and CCN2 in both ovarian cancer cells. Furthermore, the increase in CCN1/CCN2 expression contributes to the S1P-induced increase in cancer cell proliferation. äSphingosine-1-phosphate promotes ovarian cancer cell proliferation by (epmc).pdf DeepDyve Pubget Overpricing