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Anti-MDA5 antibody as a potential diagnostic and prognostic biomarker in patients
with dermatomyositis
#MMPMID28460448
Li L
; Wang Q
; Yang F
; Wu C
; Chen S
; Wen X
; Liu C
; Li Y
Oncotarget
2017[Apr]; 8
(16
): 26552-26564
PMID28460448
show ga
The presence of anti-MDA5 antibodies in serum represents an important biomarker
in the diagnosis and prediction of prognosis for patients with idiopathic
inflammatory myopathies (IIMs). Due to conflicting results that have been
reported regarding the detection of anti-MDA5 antibodies, the goal of this study
was to assess a potential association between the presence of anti-MDA5
antibodies and dermatomyositis/polymyositis (DM/PM), as well as the diagnostic
and prognostic values of anti-MDA5 antibodies for DM/PM. For this, a review of
literature published prior to October 15, 2016 was conducted. Eight studies with
286 PM patients and 216 healthy controls and nine studies with 628 DM patients
and 221 healthy controls were selected according to specific inclusion criteria.
The outcomes of these studies revealed that the presence of anti-MDA5 antibodies
was associated with DM, especially CADM, and not with PM. Furthermore, the pooled
sensitivity, specificity, and area under the curve (AUC) values were 0.62 (95%
confidence interval (CI): 0.52-0.70), 1.00 (95% CI: 0.97-1.00), and 0.9381 for
CADM patients versus healthy controls when an immunoprecipitation method was
used. The presence of anti-MDA5 antibodies was also found to be significantly
associated with an increased risk of death in DM (relative risk = 3.32, 95% CI:
1.65-6.67, P = 0.001). These findings suggest that anti-MDA5 antibodies correlate
with DM and could be used as a biomarker in the clinical diagnosis of CADM. The
presence of anti-MDA5 antibodies was also associated with poor prognosis
regarding the overall survival of patients with DM.
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