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10.18632/oncotarget.15518 http://scihub22266oqcxt.onion/10.18632/oncotarget.15518 C5432272!5432272 !28460437     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28460437 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncotarget 2017 ; 8 (16 ): 26460-26470 Nephropedia Template TP {{tp|p=28460437 |t=2017. Trichosanthin increases Granzyme B penetration into tumor cells by upregulation of CI-MPR on the cell surface |pdf=|usr=}}{{28460437 }} gab.com Text Trichosanthin increases Granzyme B penetration into tumor cells by upregulation of CI-MPR on the cell surface JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28460437 #FOAvip Trichosanthin is a plant toxin belonging to the family of ribosome-inactivating proteins. It has various biological and pharmacological activities, including anti-tumor and immunoregulatory effects. In this study, we explored the potential medicinal applications of trichosanthin in cancer immunotherapy. We found that trichosanthin and cation-independent mannose-6-phosphate receptor competitively bind to the Golgi-localized, ?-ear containing and Arf-binding proteins. It in turn promotes the translocation of cation-independent mannose-6-phosphate receptor from the cytosol to the plasma membrane, which is a receptor of Granzyme B. The upregulation of this receptor on the tumor cell surface increased the cell permeability to Granzyme B, and the latter is one of the major factors of cytotoxic T lymphocyte-mediated tumor cell apoptosis. These results suggest a novel potential application of trichosanthin and shed light on its anti-tumor immunotherapy. Twit Text FOAVip Trichosanthin increases Granzyme B penetration into tumor cells by upregulation of CI-MPR on the cell surface ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28460437 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28460437 #FOAvip English Wikipedia <ref>{{Cite pmid|28460437 }}</ref> Trichosanthin increases Granzyme B penetration into tumor cells by upregulation of CI-MPR on the cell surface #MMPMID28460437 Li C ; Zeng M ; Chi H ; Shen J ; Ng TB ; Jin G ; Lu D ; Fan X ; Xiong B ; Xiao Z ; Sha O Oncotarget 2017[Apr]; 8 (16 ): 26460-26470 PMID28460437 show ga Trichosanthin is a plant toxin belonging to the family of ribosome-inactivating proteins. It has various biological and pharmacological activities, including anti-tumor and immunoregulatory effects. In this study, we explored the potential medicinal applications of trichosanthin in cancer immunotherapy. We found that trichosanthin and cation-independent mannose-6-phosphate receptor competitively bind to the Golgi-localized, ?-ear containing and Arf-binding proteins. It in turn promotes the translocation of cation-independent mannose-6-phosphate receptor from the cytosol to the plasma membrane, which is a receptor of Granzyme B. The upregulation of this receptor on the tumor cell surface increased the cell permeability to Granzyme B, and the latter is one of the major factors of cytotoxic T lymphocyte-mediated tumor cell apoptosis. These results suggest a novel potential application of trichosanthin and shed light on its anti-tumor immunotherapy. |Amino Acid Sequence [MESH] |Animals [MESH] |Apoptosis [MESH] |Cell Line, Tumor [MESH] |Cell Membrane Permeability [MESH] |Cell Membrane/*metabolism [MESH] |Disease Models, Animal [MESH] |Granzymes/*metabolism [MESH] |Humans [MESH] |Male [MESH] |Mice [MESH] |Protein Binding [MESH] |Protein Interaction Domains and Motifs [MESH] |Receptor, IGF Type 2/*metabolism [MESH] |Trichosanthin/chemistry/*metabolism [MESH]Trichosanthin increases Granzyme B penetration into tumor cells by upr(epmc).pdf DeepDyve Pubget Overpricing