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10.18632/oncotarget.15401 http://scihub22266oqcxt.onion/10.18632/oncotarget.15401 C5432228!5432228 !28412730     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28412730 &cmd=llinks): Failed to open stream: HTTP request failed! 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The long noncoding RNA, treRNA, decreases DNA damage and is associated with poor response to chemotherapy in chronic lymphocytic leukemia |pdf=|usr=}}{{28412730 }} gab.com Text The long noncoding RNA, treRNA, decreases DNA damage and is associated with poor response to chemotherapy in chronic lymphocytic leukemia JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28412730 #FOAvip The study of long noncoding RNAs (lncRNAs) is an emerging area of cancer research, in part due to their ability to serve as disease biomarkers. However, few studies have investigated lncRNAs in chronic lymphocytic leukemia (CLL). We have identified one particular lncRNA, treRNA, which is overexpressed in CLL B-cells. We measured transcript expression in 144 CLL patient samples and separated samples into high or low expression of treRNA relative to the overall median. We found that high expression of treRNA is significantly associated with shorter time to treatment. High treRNA also correlates with poor prognostic indicators such as unmutated IGHV and high ZAP70 protein expression. We validated these initial findings in samples collected in a clinical trial comparing the nucleoside analog fludarabine alone or in combination with the alkylating agent cyclophosphamide in untreated CLL samples collected prior to starting therapy (E2997). High expression of treRNA was independently prognostic for shorter progression free survival in patients receiving fludarabine plus cyclophosphamide. Given these results, in order to study the role of treRNA in DNA damage response we generated a model cell line system where treRNA was over-expressed in the human B-CLL cell line OSU-CLL. Relative to the vector control line, there was less cell death in OSU-CLL over-expressing treRNA after exposure to fludarabine and mafosfamide, due in part to a reduction in DNA damage. Therefore, we suggest that treRNA is a novel biomarker in CLL associated with aggressive disease and poor response to chemotherapy through enhanced protection against cytotoxic mediated DNA damage. Twit Text FOAVip The long noncoding RNA, treRNA, decreases DNA damage and is associated with poor response to chemotherapy in chronic lymphocytic leukemia ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28412730 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28412730 #FOAvip English Wikipedia <ref>{{Cite pmid|28412730 }}</ref> The long noncoding RNA, treRNA, decreases DNA damage and is associated with poor response to chemotherapy in chronic lymphocytic leukemia #MMPMID28412730 Miller CR ; Ruppert AS ; Fobare S ; Chen TL ; Liu C ; Lehman A ; Blachly JS ; Zhang X ; Lucas DM ; Grever MR ; Tallman MS ; Flinn IW ; Rassenti LZ ; Kipps TJ ; Sampath D ; Coombes KR ; Hertlein EK Oncotarget 2017[Apr]; 8 (16 ): 25942-25954 PMID28412730 show ga The study of long noncoding RNAs (lncRNAs) is an emerging area of cancer research, in part due to their ability to serve as disease biomarkers. However, few studies have investigated lncRNAs in chronic lymphocytic leukemia (CLL). We have identified one particular lncRNA, treRNA, which is overexpressed in CLL B-cells. We measured transcript expression in 144 CLL patient samples and separated samples into high or low expression of treRNA relative to the overall median. We found that high expression of treRNA is significantly associated with shorter time to treatment. High treRNA also correlates with poor prognostic indicators such as unmutated IGHV and high ZAP70 protein expression. We validated these initial findings in samples collected in a clinical trial comparing the nucleoside analog fludarabine alone or in combination with the alkylating agent cyclophosphamide in untreated CLL samples collected prior to starting therapy (E2997). High expression of treRNA was independently prognostic for shorter progression free survival in patients receiving fludarabine plus cyclophosphamide. Given these results, in order to study the role of treRNA in DNA damage response we generated a model cell line system where treRNA was over-expressed in the human B-CLL cell line OSU-CLL. Relative to the vector control line, there was less cell death in OSU-CLL over-expressing treRNA after exposure to fludarabine and mafosfamide, due in part to a reduction in DNA damage. Therefore, we suggest that treRNA is a novel biomarker in CLL associated with aggressive disease and poor response to chemotherapy through enhanced protection against cytotoxic mediated DNA damage. |*DNA Damage [MESH] |*RNA, Long Noncoding [MESH] |Adult [MESH] |Aged [MESH] |Aged, 80 and over [MESH] |Antineoplastic Combined Chemotherapy Protocols/adverse effects/therapeutic use [MESH] |Biomarkers [MESH] |Female [MESH] |Gene Expression [MESH] |Humans [MESH] |Leukemia, Lymphocytic, Chronic, B-Cell/drug therapy/*genetics/*mortality/pathology [MESH] |Male [MESH] |Middle Aged [MESH] |Prognosis [MESH] |Treatment Outcome [MESH]The long noncoding RNA, treRNA, decreases DNA damage and is associated(epmc).pdf DeepDyve Pubget Overpricing