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10.1097/CCM.0000000000002310

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suck abstract from ncbi


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pmid28333760
      Crit+Care+Med 2017 ; 45 (6 ): e600-e606
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  • Antibiotic-Associated Apoptotic Enterocolitis in the Absence of a Defined Pathogen: The Role of Intestinal Microbiota Depletion #MMPMID28333760
  • Wurm P ; Spindelboeck W ; Krause R ; Plank J ; Fuchs G ; Bashir M ; Petritsch W ; Halwachs B ; Langner C ; Högenauer C ; Gorkiewicz G
  • Crit Care Med 2017[Jun]; 45 (6 ): e600-e606 PMID28333760 show ga
  • OBJECTIVE: Antibiotic therapy is a major risk factor for the development of diarrhea and colitis with varying severity. Often the origin of antibiotic-associated gastrointestinal deterioration remains elusive and no specific infectious agents could be discerned. PATIENTS: We represent three cases of intractable high-volume diarrhea associated with combined antibiotic and steroid therapy in critically ill patients not fitting into established disease entities. Cases presented with severe apoptotic enterocolitis resembling acute intestinal graft-versus-host-disease. Microbiologic workup precluded known enteropathogens, but microbiota analysis revealed a severely depleted gut microbiota with concomitant opportunistic pathogen overgrowth. INTERVENTIONS: Fecal microbiota transplantation, performed in one patient, was associated with correction of dysbiosis, rapid clinical improvement, and healing of enterocolitis. CONCLUSIONS: Our series represents a severe form of antibiotic-associated colitis in critically ill patients signified by microbiota depletion, and reestablishment of a physiologic gastrointestinal microbiota might be beneficial for this condition.
  • |Adolescent [MESH]
  • |Adult [MESH]
  • |Anti-Bacterial Agents/*adverse effects [MESH]
  • |Enterocolitis/*chemically induced/*microbiology/therapy [MESH]
  • |Fecal Microbiota Transplantation/methods [MESH]
  • |Female [MESH]
  • |Gastrointestinal Microbiome/*drug effects [MESH]
  • |Humans [MESH]
  • |Male [MESH]


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