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2017 ; 22
(3
): e307-e313
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Histopathological characterization of the oral lichenoid disease subtypes and the
relation with the clinical data
#MMPMID28390133
Alberdi-Navarro J
; Marichalar-Mendia X
; Lartitegui-Sebastián MJ
; Gainza-Cirauqui ML
; Echebarria-Goikouria MA
; Aguirre-Urizar JM
Med Oral Patol Oral Cir Bucal
2017[May]; 22
(3
): e307-e313
PMID28390133
show ga
BACKGROUND: The aim of the study was to analyze the histopathological
characteristics of samples with a diagnosis of oral lichenoid disease (OLD) and
their link with the location and the type of clinical lesion, and the
clinicopathological subtypes. MATERIAL AND METHODS: Retrospective study on 85
consecutive patients diagnosed with OLD (58 women and 27 men, mean age of 57.7
years). Clinical and histopathological characterization of each case (modified
WHO criteria). Collection of the clinical and histopathological data of the
lesions. Descriptive and comparative statistical analysis of the results.
RESULTS: The 78.8% of the cases were considered clinically typical while the
21.2% were considered compatible. Histologically, 52.9% were classified as
typical and 47.1% as compatible. Biopsies from "plaque-like" lesions presented
hyperkeratosis (p>0.001) and epithelial dysplasia (p=0.06) more frequently.
Furthermore, acute inflammation was more evident in erosive-ulcerative lesions
(p=0.001). Differences regarding the location of the biopsy were statistically
non-significant. However, 42.9% of the tongue biopsies showed epithelial
dysplasia. CONCLUSIONS: The histopathological aspect of this disorder is not
specific and does not allow us to differentiate between the main subtypes.
Therefore, the main reasons to perform a biopsy in this disorder are to define
the differential diagnosis and to rule out epithelial dysplasia or a carcinoma.
The final histopathological result may be subject to the type of lesion that is
biopsied.