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10.1038/s41467-017-00018-4 http://scihub22266oqcxt.onion/10.1038/s41467-017-00018-4 C5432035!5432035 !28473692     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28473692 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Commun 2017 ; 8 (1 ): 16 Nephropedia Template TP {{tp|p=28473692 |t=2017. Blue light regenerates functional visual pigments in mammals through a retinyl-phospholipid intermediate |pdf=|usr=}}{{28473692 }} gab.com Text Blue light regenerates functional visual pigments in mammals through a retinyl-phospholipid intermediate JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28473692 #FOAvip The light absorbing chromophore in opsin visual pigments is the protonated Schiff base of 11-cis-retinaldehyde (11cRAL). Absorption of a photon isomerizes 11cRAL to all-trans-retinaldehyde (atRAL), briefly activating the pigment before it dissociates. Light sensitivity is restored when apo-opsin combines with another 11cRAL to form a new visual pigment. Conversion of atRAL to 11cRAL is carried out by enzyme pathways in neighboring cells. Here we show that blue (450-nm) light converts atRAL specifically to 11cRAL through a retinyl-phospholipid intermediate in photoreceptor membranes. The quantum efficiency of this photoconversion is similar to rhodopsin. Photoreceptor membranes synthesize 11cRAL chromophore faster under blue light than in darkness. Live mice regenerate rhodopsin more rapidly in blue light. Finally, whole retinas and isolated cone cells show increased photosensitivity following exposure to blue light. These results indicate that light contributes to visual-pigment renewal in mammalian rods and cones through a non-enzymatic process involving retinyl-phospholipids.It is currently thought that visual pigments in vertebrate photoreceptors are regenerated exclusively through enzymatic cycles. Here the authors show that mammalian photoreceptors also regenerate opsin pigments in light through photoisomerization of N-ret-PE (N-retinylidene-phosphatidylethanolamine. Twit Text FOAVip Blue light regenerates functional visual pigments in mammals through a retinyl-phospholipid intermediate ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28473692 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28473692 #FOAvip English Wikipedia <ref>{{Cite pmid|28473692 }}</ref> Blue light regenerates functional visual pigments in mammals through a retinyl-phospholipid intermediate #MMPMID28473692 Kaylor JJ ; Xu T ; Ingram NT ; Tsan A ; Hakobyan H ; Fain GL ; Travis GH Nat Commun 2017[May]; 8 (1 ): 16 PMID28473692 show ga The light absorbing chromophore in opsin visual pigments is the protonated Schiff base of 11-cis-retinaldehyde (11cRAL). Absorption of a photon isomerizes 11cRAL to all-trans-retinaldehyde (atRAL), briefly activating the pigment before it dissociates. Light sensitivity is restored when apo-opsin combines with another 11cRAL to form a new visual pigment. Conversion of atRAL to 11cRAL is carried out by enzyme pathways in neighboring cells. Here we show that blue (450-nm) light converts atRAL specifically to 11cRAL through a retinyl-phospholipid intermediate in photoreceptor membranes. The quantum efficiency of this photoconversion is similar to rhodopsin. Photoreceptor membranes synthesize 11cRAL chromophore faster under blue light than in darkness. Live mice regenerate rhodopsin more rapidly in blue light. Finally, whole retinas and isolated cone cells show increased photosensitivity following exposure to blue light. These results indicate that light contributes to visual-pigment renewal in mammalian rods and cones through a non-enzymatic process involving retinyl-phospholipids.It is currently thought that visual pigments in vertebrate photoreceptors are regenerated exclusively through enzymatic cycles. Here the authors show that mammalian photoreceptors also regenerate opsin pigments in light through photoisomerization of N-ret-PE (N-retinylidene-phosphatidylethanolamine. |Animals [MESH] |Apoproteins/genetics/metabolism [MESH] |Gene Expression Regulation [MESH] |Light [MESH] |Light Signal Transduction [MESH] |Mice [MESH] |Opsins/genetics/metabolism [MESH] |Phosphatidylethanolamines/*metabolism [MESH] |Photochemical Processes [MESH] |Retinal Cone Photoreceptor Cells/cytology/metabolism/*radiation effects [MESH] |Retinal Rod Photoreceptor Cells/cytology/metabolism/*radiation effects [MESH] |Retinaldehyde/*metabolism [MESH] |Retinoids/*metabolism [MESH] |Rhodopsin/genetics/*metabolism [MESH] |Transducin/genetics/metabolism [MESH]Blue light regenerates functional visual pigments in mammals through a(epmc).pdf DeepDyve Pubget Overpricing