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10.1038/s41598-017-02041-3 http://scihub22266oqcxt.onion/10.1038/s41598-017-02041-3 C5431856!5431856!28500337     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2017 ; 7 (ä): ä Nephropedia Template TP {{tp|p=28500337|t=2017. Examining the efficacy of intravenous administration of predatory bacteria in rats |pdf=|usr=}}{{28500337}} gab.com Text Examining the efficacy of intravenous administration of predatory bacteria in rats JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28500337 #FOAvip The proteobacteria Bdellovibrio bacteriovorus and Micavibrio aeruginosavorus are obligate predators of Gram-negative bacteria, and have been proposed to be used to treat multidrug-resistant bacterial infections. The ability of predatory bacteria to reduce bacterial burden in vivo within the lungs of rats has been demonstrated, but it was unknown if predatory bacteria can attenuate systemic bacterial burden administered intravenously. In this study, we first assessed the safety of intravenous inoculation of predatory bacteria in rats. No rat morbidity or adverse histopathology of various organs due to predatory bacteria administration was observed. An increase in proinflammatory cytokines (TNF? and KC/GRO) was observed at two hours post-inoculation; however, cytokines returned to baseline levels by 18?hours. Furthermore, bacterial dissemination analysis demonstrated that predatory bacteria were efficiently cleared from the host by 20 days post-injection. To determine whether predatory bacteria could reduce bacterial burden in vivo, Klebsiella pneumoniae was injected into the tail veins of rats and followed with multiple doses of predatory bacteria over 16 or 24?hours. Predatory bacteria were unable to significantly reduce K. pneumoniae burden in the blood or prevent dissemination to other organs. The results suggest that predatory bacteria may not be effective for treatment of acute blood infections. Twit Text FOAVip Examining the efficacy of intravenous administration of predatory bacteria in rats ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28500337 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28500337 #FOAvip English Wikipedia <ref>{{Cite pmid|28500337}}</ref> Examining the efficacy of intravenous administration of predatory bacteria in rats #MMPMID28500337 Shatzkes K; Singleton E; Tang C; Zuena M; Shukla S; Gupta S; Dharani S; Rinaggio J; Kadouri DE; Connell ND Sci Rep 2017[]; 7 (ä): ä PMID28500337show ga The proteobacteria Bdellovibrio bacteriovorus and Micavibrio aeruginosavorus are obligate predators of Gram-negative bacteria, and have been proposed to be used to treat multidrug-resistant bacterial infections. The ability of predatory bacteria to reduce bacterial burden in vivo within the lungs of rats has been demonstrated, but it was unknown if predatory bacteria can attenuate systemic bacterial burden administered intravenously. In this study, we first assessed the safety of intravenous inoculation of predatory bacteria in rats. No rat morbidity or adverse histopathology of various organs due to predatory bacteria administration was observed. An increase in proinflammatory cytokines (TNF? and KC/GRO) was observed at two hours post-inoculation; however, cytokines returned to baseline levels by 18?hours. Furthermore, bacterial dissemination analysis demonstrated that predatory bacteria were efficiently cleared from the host by 20 days post-injection. To determine whether predatory bacteria could reduce bacterial burden in vivo, Klebsiella pneumoniae was injected into the tail veins of rats and followed with multiple doses of predatory bacteria over 16 or 24?hours. Predatory bacteria were unable to significantly reduce K. pneumoniae burden in the blood or prevent dissemination to other organs. The results suggest that predatory bacteria may not be effective for treatment of acute blood infections. äExamining the efficacy of intravenous administration of predatory bact(epmc).pdf DeepDyve Pubget Overpricing