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10.1038/s41598-017-01743-y http://scihub22266oqcxt.onion/10.1038/s41598-017-01743-y C5431478!5431478!28484249     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2017 ; 7 (ä): ä Nephropedia Template TP {{tp|p=28484249|t=2017. DNA Methyltransferase1 (DNMT1) Isoform3 methylates mitochondrial genome and modulates its biology |pdf=|usr=}}{{28484249}} gab.com Text DNA Methyltransferase1 (DNMT1) Isoform3 methylates mitochondrial genome and modulates its biology JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28484249 #FOAvip Here we demonstrate localization of the isoform3 of DNA Methyltransferase1 (DNMT1) enzyme to mitochondria, instead of isoform1 as reported earlier. The fused DNMT1-isoform1, reported earlier to localize in mitochondria, surprisingly showed its exclusive presence inside the nucleus after its ectopic expression; and failed to localize in mitochondria. On the other hand, ectopically expressed DNMT1-isoform3 targeted itself to mitochondria and subsequently methylated CpG regions in the mitochondrial genome. In addition, overexpression of DNMT1-isoform3 affected mitochondrial biology and regulated its function. Under different conditions of oxidative and nutritional stress, this isoform was down-regulated, resulting in hypomethylation of mitochondrial genome. Our study reveals how DNMT1-isoform3, instead of isoform1, is responsible for mtDNA methylation, influencing its biology. Twit Text FOAVip DNA Methyltransferase1 (DNMT1) Isoform3 methylates mitochondrial genome and modulates its biology ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28484249 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28484249 #FOAvip English Wikipedia <ref>{{Cite pmid|28484249}}</ref> DNA Methyltransferase1 (DNMT1) Isoform3 methylates mitochondrial genome and modulates its biology #MMPMID28484249 Saini SK; Mangalhara KC; Prakasam G; Bamezai RNK Sci Rep 2017[]; 7 (ä): ä PMID28484249show ga Here we demonstrate localization of the isoform3 of DNA Methyltransferase1 (DNMT1) enzyme to mitochondria, instead of isoform1 as reported earlier. The fused DNMT1-isoform1, reported earlier to localize in mitochondria, surprisingly showed its exclusive presence inside the nucleus after its ectopic expression; and failed to localize in mitochondria. On the other hand, ectopically expressed DNMT1-isoform3 targeted itself to mitochondria and subsequently methylated CpG regions in the mitochondrial genome. In addition, overexpression of DNMT1-isoform3 affected mitochondrial biology and regulated its function. Under different conditions of oxidative and nutritional stress, this isoform was down-regulated, resulting in hypomethylation of mitochondrial genome. Our study reveals how DNMT1-isoform3, instead of isoform1, is responsible for mtDNA methylation, influencing its biology. äDNA Methyltransferase1 (DNMT1) Isoform3 methylates mitochondrial genom(epmc).pdf DeepDyve Pubget Overpricing