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10.3892/ol.2017.5869

http://scihub22266oqcxt.onion/10.3892/ol.2017.5869
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C5431332!5431332!28521484
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suck abstract from ncbi


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pmid28521484      Oncol+Lett 2017 ; 13 (5): 3845-9
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  • MicroRNA-429 inhibits gastric cancer migration and invasion through the downregulation of specificity protein 1 #MMPMID28521484
  • Ni J; Yang Y; Liu D; Sun H; Jin S; Li J
  • Oncol Lett 2017[May]; 13 (5): 3845-9 PMID28521484show ga
  • microRNAs (miRs) have been reported to have an important role in tumorigenesis and tumor progression. Although miR-429 has been shown to be downregulated in gastric cancer (GC), the function of miR-429 in the metastasis of GC has yet to be investigated. In the present study, GC cells were transfected with miR-429, and reverse transcription-quantitative polymerase chain reaction, cell migration assays, cell invasion assays, western blot analysis and luciferase assays were conducted to investigate the role of miR-429 in GC cells. It was demonstrated that miR-429 expression was markedly increased following transfection of the cells with miR-429. Furthermore, miR-429 was shown to inhibit the migration and invasion of GC cell lines. In addition, this study provided evidence that miR-429 directly targets specificity protein 1 in GC cells. The results of the present study may enhance current knowledge regarding the molecular basis of cancer metastasis and provide a potential therapeutic strategy for GC.
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