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MicroRNA-429 inhibits gastric cancer migration and invasion through the
downregulation of specificity protein 1
#MMPMID28521484
Ni J
; Yang Y
; Liu D
; Sun H
; Jin S
; Li J
Oncol Lett
2017[May]; 13
(5
): 3845-3849
PMID28521484
show ga
microRNAs (miRs) have been reported to have an important role in tumorigenesis
and tumor progression. Although miR-429 has been shown to be downregulated in
gastric cancer (GC), the function of miR-429 in the metastasis of GC has yet to
be investigated. In the present study, GC cells were transfected with miR-429,
and reverse transcription-quantitative polymerase chain reaction, cell migration
assays, cell invasion assays, western blot analysis and luciferase assays were
conducted to investigate the role of miR-429 in GC cells. It was demonstrated
that miR-429 expression was markedly increased following transfection of the
cells with miR-429. Furthermore, miR-429 was shown to inhibit the migration and
invasion of GC cell lines. In addition, this study provided evidence that miR-429
directly targets specificity protein 1 in GC cells. The results of the present
study may enhance current knowledge regarding the molecular basis of cancer
metastasis and provide a potential therapeutic strategy for GC.
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