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10.1038/s41598-017-01665-9

http://scihub22266oqcxt.onion/10.1038/s41598-017-01665-9
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C5431189!5431189!28469179
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suck abstract from ncbi


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pmid28469179      Sci+Rep 2017 ; 7 (ä): ä
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  • Highly Selective and Sensitive Self-Powered Glucose Sensor Based on Capacitor Circuit #MMPMID28469179
  • Slaughter G; Kulkarni T
  • Sci Rep 2017[]; 7 (ä): ä PMID28469179show ga
  • Enzymatic glucose biosensors are being developed to incorporate nanoscale materials with the biological recognition elements to assist in the rapid and sensitive detection of glucose. Here we present a highly sensitive and selective glucose sensor based on capacitor circuit that is capable of selectively sensing glucose while simultaneously powering a small microelectronic device. Multi-walled carbon nanotubes (MWCNTs) is chemically modified with pyrroloquinoline quinone glucose dehydrogenase (PQQ-GDH) and bilirubin oxidase (BOD) at anode and cathode, respectively, in the biofuel cell arrangement. The input voltage (as low as 0.25?V) from the biofuel cell is converted to a stepped-up power and charged to the capacitor to the voltage of 1.8?V. The frequency of the charge/discharge cycle of the capacitor corresponded to the oxidation of glucose. The biofuel cell structure-based glucose sensor synergizes the advantages of both the glucose biosensor and biofuel cell. In addition, this glucose sensor favored a very high selectivity towards glucose in the presence of competing and non-competing analytes. It exhibited unprecedented sensitivity of 37.66?Hz/mM.cm2 and a linear range of 1 to 20?mM. This innovative self-powered glucose sensor opens new doors for implementation of biofuel cells and capacitor circuits for medical diagnosis and powering therapeutic devices.
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