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10.1038/s41598-017-01411-1 http://scihub22266oqcxt.onion/10.1038/s41598-017-01411-1 C5431161!5431161!28469254     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2017 ; 7 (ä): ä Nephropedia Template TP {{tp|p=28469254|t=2017. Immune-checkpoint protein VISTA critically regulates the IL-23/IL-17 inflammatory axis |pdf=|usr=}}{{28469254}} gab.com Text Immune-checkpoint protein VISTA critically regulates the IL-23/IL-17 inflammatory axis JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28469254 #FOAvip V-domain Immunoglobulin Suppressor of T cell Activation (VISTA) is an inhibitory immune-checkpoint molecule that suppresses CD4+ and CD8+ T cell activation when expressed on antigen-presenting cells. Vsir?/? mice developed loss of peripheral tolerance and multi-organ chronic inflammatory phenotypes. Vsir?/? CD4+ and CD8+ T cells were hyper-responsive towards self- and foreign antigens. Whether or not VISTA regulates innate immunity is unknown. Using a murine model of psoriasis induced by TLR7 agonist imiquimod (IMQ), we show that VISTA deficiency exacerbated psoriasiform inflammation. Enhanced TLR7 signaling in Vsir?/? dendritic cells (DCs) led to the hyper-activation of Erk1/2 and Jnk1/2, and augmented the production of IL-23. IL-23, in turn, promoted the expression of IL-17A in both TCR??+ T cells and CD4+ Th17 cells. Furthermore, VISTA regulates the peripheral homeostasis of CD27? ?? T cells and their activation upon TCR-mediated or cytokine-mediated stimulation. IL-17A-producing CD27? ?? T cells were expanded in the Vsir?/? mice and amplified the inflammatory cascade. In conclusion, this study has demonstrated that VISTA critically regulates the inflammatory responses mediated by DCs and IL-17-producing TCR??+ and CD4+ Th17 T cells following TLR7 stimulation. Our finding provides a rationale for therapeutically enhancing VISTA-mediated pathways to benefit the treatment of autoimmune and inflammatory disorders. Twit Text FOAVip Immune-checkpoint protein VISTA critically regulates the IL-23/IL-17 inflammatory axis ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28469254 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28469254 #FOAvip English Wikipedia <ref>{{Cite pmid|28469254}}</ref> Immune-checkpoint protein VISTA critically regulates the IL-23/IL-17 inflammatory axis #MMPMID28469254 Li N; Xu W; Yuan Y; Ayithan N; Imai Y; Wu X; Miller H; Olson M; Feng Y; Huang YH; Jo Turk M; Hwang ST; Malarkannan S; Wang L Sci Rep 2017[]; 7 (ä): ä PMID28469254show ga V-domain Immunoglobulin Suppressor of T cell Activation (VISTA) is an inhibitory immune-checkpoint molecule that suppresses CD4+ and CD8+ T cell activation when expressed on antigen-presenting cells. Vsir?/? mice developed loss of peripheral tolerance and multi-organ chronic inflammatory phenotypes. Vsir?/? CD4+ and CD8+ T cells were hyper-responsive towards self- and foreign antigens. Whether or not VISTA regulates innate immunity is unknown. Using a murine model of psoriasis induced by TLR7 agonist imiquimod (IMQ), we show that VISTA deficiency exacerbated psoriasiform inflammation. Enhanced TLR7 signaling in Vsir?/? dendritic cells (DCs) led to the hyper-activation of Erk1/2 and Jnk1/2, and augmented the production of IL-23. IL-23, in turn, promoted the expression of IL-17A in both TCR??+ T cells and CD4+ Th17 cells. Furthermore, VISTA regulates the peripheral homeostasis of CD27? ?? T cells and their activation upon TCR-mediated or cytokine-mediated stimulation. IL-17A-producing CD27? ?? T cells were expanded in the Vsir?/? mice and amplified the inflammatory cascade. In conclusion, this study has demonstrated that VISTA critically regulates the inflammatory responses mediated by DCs and IL-17-producing TCR??+ and CD4+ Th17 T cells following TLR7 stimulation. Our finding provides a rationale for therapeutically enhancing VISTA-mediated pathways to benefit the treatment of autoimmune and inflammatory disorders. äImmune-checkpoint protein VISTA critically regulates the IL-23/IL-17 i(epmc).pdf DeepDyve Pubget Overpricing