Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1111/jcmm.13056 http://scihub22266oqcxt.onion/10.1111/jcmm.13056 C5431139!5431139!28026121     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28026121.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Cell+Mol+Med 2017 ; 21 (6): 1228-36 Nephropedia Template TP {{tp|p=28026121|t=2017. Circulating exosomal microRNA?96 promotes cell proliferation, migration and drug resistance by targeting LMO7 |pdf=|usr=}}{{28026121}} gab.com Text Circulating exosomal microRNA 96 promotes cell proliferation, migration and drug resistance by targeting LMO7 JO: J Cell Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=28026121 #FOAvip Detection and treatment of lung cancer still remain a clinical challenge. This study aims to validate exosomal microRNA?96 (miR?96) as a serum biomarker for lung cancer and understand the underlying mechanism in lung cancer progression. MiR?96 expressions in normal and lung cancer patients were characterized by qPCR analysis. Changes in cell viability, migration and cisplatin resistance were monitored after incubation with isolated miR?96?containing exosomes, anti?miR?96 and anti?miR negative control (anti?miR?NC) transfections. Dual?luciferase reporter assay was used to study interaction between miR?96 and LIM?domain only protein 7 (LMO7). Changes induced by miR?96 transfection and LMO7 overexpression were also evaluated. MiR?96 expression was positively correlated with high?grade and metastatic lung cancers. While anti?miR?96 transfection exhibited a tumour?suppressing function, exosomes isolated from H1299 enhanced cell viability, migration and cisplatin resistance. Potential miR?96 binding sites were found within the 3??UTR of wild?type LMO7 gene, but not of mutant LMO7 gene. LMO7 expression was inversely correlated with lung cancer grades, and LMO7 overexpression reversed promoting effect of miR?96. We have identified exosomal miR?96 as a serum biomarker of malignant lung cancer. MiR?96 promotes lung cancer progression by targeting LMO7. The miR?96?LMO7 axis may be a therapeutic target for lung cancer patients, and new diagnostic or therapeutic strategies could be developed by targeting the miR?96?LMO7 axis. Twit Text FOAVip Circulating exosomal microRNA 96 promotes cell proliferation, migration and drug resistance by targeting LMO7 ????J Cell Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=28026121 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28026121 #FOAvip English Wikipedia <ref>{{Cite pmid|28026121}}</ref> Circulating exosomal microRNA?96 promotes cell proliferation, migration and drug resistance by targeting LMO7 #MMPMID28026121 Wu H; Zhou J; Mei S; Wu D; Mu Z; Chen B; Xie Y; Ye Y; Liu J J Cell Mol Med 2017[Jun]; 21 (6): 1228-36 PMID28026121show ga Detection and treatment of lung cancer still remain a clinical challenge. This study aims to validate exosomal microRNA?96 (miR?96) as a serum biomarker for lung cancer and understand the underlying mechanism in lung cancer progression. MiR?96 expressions in normal and lung cancer patients were characterized by qPCR analysis. Changes in cell viability, migration and cisplatin resistance were monitored after incubation with isolated miR?96?containing exosomes, anti?miR?96 and anti?miR negative control (anti?miR?NC) transfections. Dual?luciferase reporter assay was used to study interaction between miR?96 and LIM?domain only protein 7 (LMO7). Changes induced by miR?96 transfection and LMO7 overexpression were also evaluated. MiR?96 expression was positively correlated with high?grade and metastatic lung cancers. While anti?miR?96 transfection exhibited a tumour?suppressing function, exosomes isolated from H1299 enhanced cell viability, migration and cisplatin resistance. Potential miR?96 binding sites were found within the 3??UTR of wild?type LMO7 gene, but not of mutant LMO7 gene. LMO7 expression was inversely correlated with lung cancer grades, and LMO7 overexpression reversed promoting effect of miR?96. We have identified exosomal miR?96 as a serum biomarker of malignant lung cancer. MiR?96 promotes lung cancer progression by targeting LMO7. The miR?96?LMO7 axis may be a therapeutic target for lung cancer patients, and new diagnostic or therapeutic strategies could be developed by targeting the miR?96?LMO7 axis. äCirculating exosomal microRNA?96 promotes cell proliferation, migratio(epmc).pdf DeepDyve Pubget Overpricing