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10.1111/jcmm.13040 http://scihub22266oqcxt.onion/10.1111/jcmm.13040 C5431129!5431129 !27957800     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27957800 &cmd=llinks): Failed to open stream: HTTP request failed! 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CARD9 gene silencing with siRNA protects rats against severe acute pancreatitis: CARD9-dependent NF-?B and P38MAPKs pathway |pdf=|usr=}}{{27957800 }} gab.com Text CARD9 gene silencing with siRNA protects rats against severe acute pancreatitis: CARD9-dependent NF- B and P38MAPKs pathway JO: J Cell Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=27957800 #FOAvip We previously reported the up-regulation of caspase recruitment domain 9 (CARD9) expressions in severe acute pancreatitis (SAP) patients, but little is known about its regulation. In this study, small interfering RNA (siRNA) was used to reduce the levels of CARD9 expression in sodium taurocholate-stimulated SAP rats. CARD9 was overexpressed in SAP rats, which correlated with the severity of pancreatitis. When compared to the untreated group, the cohort that received the siRNA treatment demonstrated a significant reduction in pancreatic injury, neutrophil infiltration, myeloperoxidase activity and pro-inflammatory cytokines. Furthermore, siRNAs showed that the reduction of CARD9 in SAP rats down-regulated the expression of NF-?Bp65 and P38MAPK which are involved in the transcription and release of a wide variety of inflammatory cytokines. These findings provide evidence that CARD9 is up-regulated in SAP rats and acts as a potential therapeutic target for the treatment thereof. Blocking the activation of NF-?B and P38MAPK via siRNA-mediated gene knock-down of CARD9 appears to reduce the inflammatory response in pancreatic tissue. Twit Text FOAVip CARD9 gene silencing with siRNA protects rats against severe acute pancreatitis: CARD9-dependent NF- B and P38MAPKs pathway ????J Cell Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=27957800 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27957800 #FOAvip English Wikipedia <ref>{{Cite pmid|27957800 }}</ref> CARD9 gene silencing with siRNA protects rats against severe acute pancreatitis: CARD9-dependent NF-?B and P38MAPKs pathway #MMPMID27957800 Yang ZW ; Meng XX ; Zhang C ; Xu P J Cell Mol Med 2017[Jun]; 21 (6 ): 1085-1093 PMID27957800 show ga We previously reported the up-regulation of caspase recruitment domain 9 (CARD9) expressions in severe acute pancreatitis (SAP) patients, but little is known about its regulation. In this study, small interfering RNA (siRNA) was used to reduce the levels of CARD9 expression in sodium taurocholate-stimulated SAP rats. CARD9 was overexpressed in SAP rats, which correlated with the severity of pancreatitis. When compared to the untreated group, the cohort that received the siRNA treatment demonstrated a significant reduction in pancreatic injury, neutrophil infiltration, myeloperoxidase activity and pro-inflammatory cytokines. Furthermore, siRNAs showed that the reduction of CARD9 in SAP rats down-regulated the expression of NF-?Bp65 and P38MAPK which are involved in the transcription and release of a wide variety of inflammatory cytokines. These findings provide evidence that CARD9 is up-regulated in SAP rats and acts as a potential therapeutic target for the treatment thereof. Blocking the activation of NF-?B and P38MAPK via siRNA-mediated gene knock-down of CARD9 appears to reduce the inflammatory response in pancreatic tissue. |Animals [MESH] |CARD Signaling Adaptor Proteins/antagonists & inhibitors/*genetics [MESH] |Disease Models, Animal [MESH] |Gene Expression Regulation/genetics [MESH] |Gene Knockdown Techniques [MESH] |Gene Silencing [MESH] |Humans [MESH] |Pancreas/pathology [MESH] |Pancreatitis/chemically induced/*genetics/therapy [MESH] |RNA, Small Interfering/administration & dosage/genetics [MESH] |Rats [MESH] |Signal Transduction/genetics [MESH] |Taurocholic Acid/toxicity [MESH] |Transcription Factor RelA/*genetics [MESH]CARD9 gene silencing with siRNA protects rats against severe acute pan(epmc).pdf DeepDyve Pubget Overpricing