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10.1111/jcmm.13050 http://scihub22266oqcxt.onion/10.1111/jcmm.13050 C5431126!5431126!28158919     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28158919.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Cell+Mol+Med 2017 ; 21 (6): 1182-92 Nephropedia Template TP {{tp|p=28158919|t=2017. Zinc rescues obesity?induced cardiac hypertrophy via stimulating metallothionein to suppress oxidative stress?activated BCL10/CARD9/p38 MAPK pathway |pdf=|usr=}}{{28158919}} gab.com Text Zinc rescues obesity induced cardiac hypertrophy via stimulating metallothionein to suppress oxidative stress activated BCL10/CARD9/p38 MAPK pathway JO: J Cell Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=28158919 #FOAvip Obesity often leads to obesity?related cardiac hypertrophy (ORCH), which is suppressed by zinc?induced inactivation of p38 mitogen?activated protein kinase (p38 MAPK). In this study, we investigated the mechanisms by which zinc inactivates p38 MAPK to prevent ORCH.Mice (4?week old) were fed either high fat diet (HFD, 60% kcal fat) or normal diet (ND, 10% kcal fat) containing variable amounts of zinc (deficiency, normal and supplement) for 3 and 6 months. P38 MAPK siRNA and the p38 MAPK inhibitor SB203580 were used to suppress p38 MAPK activity in vitro and in vivo, respectively. HFD activated p38 MAPK and increased expression of B?cell lymphoma/CLL 10 (BCL10) and caspase recruitment domain family member 9 (CARD9). These responses were enhanced by zinc deficiency and attenuated by zinc supplement. Administration of SB203580 to HFD mice or specific siRNA in palmitate?treated cardiomyocytes eliminated the HFD and zinc deficiency activation of p38 MAPK, but did not significantly impact the expression of BCL10 and CARD9. In cultured cardiomyocytes, inhibition of BCL10 expression by siRNA prevented palmitate?induced increased p38 MAPK activation and atrial natriuretic peptide (ANP) expression. In contrast, inhibition of p38 MAPK prevented ANP expression, but did not affect BCL10 expression. Deletion of metallothionein abolished the protective effect of zinc on palmitate?induced up?regulation of BCL10 and phospho?p38 MAPK. HFD and zinc deficiency synergistically induce ORCH by increasing oxidative stress?mediated activation of BCL10/CARD9/p38 MAPK signalling. Zinc supplement ameliorates ORCH through activation of metallothionein to repress oxidative stress?activated BCL10 expression and p38 MAPK activation. Twit Text FOAVip Zinc rescues obesity induced cardiac hypertrophy via stimulating metallothionein to suppress oxidative stress activated BCL10/CARD9/p38 MAPK pathway ????J Cell Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=28158919 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28158919 #FOAvip English Wikipedia <ref>{{Cite pmid|28158919}}</ref> Zinc rescues obesity?induced cardiac hypertrophy via stimulating metallothionein to suppress oxidative stress?activated BCL10/CARD9/p38 MAPK pathway #MMPMID28158919 Wang S; Gu J; Xu Z; Zhang Z; Bai T; Xu J; Cai J; Barnes G; Liu Q; Freedman JH; Wang Y; Liu Q; Zheng Y; Cai L J Cell Mol Med 2017[Jun]; 21 (6): 1182-92 PMID28158919show ga Obesity often leads to obesity?related cardiac hypertrophy (ORCH), which is suppressed by zinc?induced inactivation of p38 mitogen?activated protein kinase (p38 MAPK). In this study, we investigated the mechanisms by which zinc inactivates p38 MAPK to prevent ORCH.Mice (4?week old) were fed either high fat diet (HFD, 60% kcal fat) or normal diet (ND, 10% kcal fat) containing variable amounts of zinc (deficiency, normal and supplement) for 3 and 6 months. P38 MAPK siRNA and the p38 MAPK inhibitor SB203580 were used to suppress p38 MAPK activity in vitro and in vivo, respectively. HFD activated p38 MAPK and increased expression of B?cell lymphoma/CLL 10 (BCL10) and caspase recruitment domain family member 9 (CARD9). These responses were enhanced by zinc deficiency and attenuated by zinc supplement. Administration of SB203580 to HFD mice or specific siRNA in palmitate?treated cardiomyocytes eliminated the HFD and zinc deficiency activation of p38 MAPK, but did not significantly impact the expression of BCL10 and CARD9. In cultured cardiomyocytes, inhibition of BCL10 expression by siRNA prevented palmitate?induced increased p38 MAPK activation and atrial natriuretic peptide (ANP) expression. In contrast, inhibition of p38 MAPK prevented ANP expression, but did not affect BCL10 expression. Deletion of metallothionein abolished the protective effect of zinc on palmitate?induced up?regulation of BCL10 and phospho?p38 MAPK. HFD and zinc deficiency synergistically induce ORCH by increasing oxidative stress?mediated activation of BCL10/CARD9/p38 MAPK signalling. Zinc supplement ameliorates ORCH through activation of metallothionein to repress oxidative stress?activated BCL10 expression and p38 MAPK activation. äZinc rescues obesity?induced cardiac hypertrophy via stimulating metal(epmc).pdf DeepDyve Pubget Overpricing