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10.1038/s41598-017-01625-3 http://scihub22266oqcxt.onion/10.1038/s41598-017-01625-3 C5431051!5431051 !28465534     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28465534 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2017 ; 7 (1 ): 1322 Nephropedia Template TP {{tp|p=28465534 |t=2017. Low proportion of follicular regulatory T cell in renal transplant patients with chronic antibody-mediated rejection |pdf=|usr=}}{{28465534 }} gab.com Text Low proportion of follicular regulatory T cell in renal transplant patients with chronic antibody-mediated rejection JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28465534 #FOAvip Follicular regulatory T (Tfr) cell can effectively regulate humoral immunity, but its function and mechanism in antibody-mediated rejection (AMR) after organ transplantation remains unclear. Here we detected follicular helper T (Tfh) cell subsets in 88 renal transplant patients with chronic renal allograft dysfunction (40 with AMR and 48 without AMR). The ratio of Tfr cells in renal graft tissues and peripheral blood of AMR patients significantly decreased, while the ratio of IL-21-producing Tfh cells (Tfh2 and Tfh17) significantly increased, compared to non-AMR patients. When tested in functional assays, Tfr cells from both AMR and non-AMR patients exerted equivalent inhibitory function. Tfr cell transplantation or CTLA-4 virus transfection could significantly inhibit IL-21 secretion from Tfh cells of these patients, further suppress the proliferation and differentiation of B cells. CTLA-4 blocking, IL-10 and TGF-? neutralization could partially weaken such inhibitory effect of Tfr cells. Besides, our study found that sirolimus reduced the ratio of Tfr cells, while cyclosporine and tacrolimus had no significant effect on Tfr cells. In a word, renal transplant patients with AMR have low proportion of Tfr cells but these cell exerted normal function. Twit Text FOAVip Low proportion of follicular regulatory T cell in renal transplant patients with chronic antibody-mediated rejection ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28465534 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28465534 #FOAvip English Wikipedia <ref>{{Cite pmid|28465534 }}</ref> Low proportion of follicular regulatory T cell in renal transplant patients with chronic antibody-mediated rejection #MMPMID28465534 Chen W ; Bai J ; Huang H ; Bi L ; Kong X ; Gao Y ; Han Y ; Xiao L ; Shi B Sci Rep 2017[May]; 7 (1 ): 1322 PMID28465534 show ga Follicular regulatory T (Tfr) cell can effectively regulate humoral immunity, but its function and mechanism in antibody-mediated rejection (AMR) after organ transplantation remains unclear. Here we detected follicular helper T (Tfh) cell subsets in 88 renal transplant patients with chronic renal allograft dysfunction (40 with AMR and 48 without AMR). The ratio of Tfr cells in renal graft tissues and peripheral blood of AMR patients significantly decreased, while the ratio of IL-21-producing Tfh cells (Tfh2 and Tfh17) significantly increased, compared to non-AMR patients. When tested in functional assays, Tfr cells from both AMR and non-AMR patients exerted equivalent inhibitory function. Tfr cell transplantation or CTLA-4 virus transfection could significantly inhibit IL-21 secretion from Tfh cells of these patients, further suppress the proliferation and differentiation of B cells. CTLA-4 blocking, IL-10 and TGF-? neutralization could partially weaken such inhibitory effect of Tfr cells. Besides, our study found that sirolimus reduced the ratio of Tfr cells, while cyclosporine and tacrolimus had no significant effect on Tfr cells. In a word, renal transplant patients with AMR have low proportion of Tfr cells but these cell exerted normal function. |Adult [MESH] |Antibodies/immunology [MESH] |B-Lymphocytes/immunology [MESH] |CTLA-4 Antigen/immunology [MESH] |Cell Differentiation [MESH] |Cell Proliferation [MESH] |Female [MESH] |Graft Rejection/*immunology [MESH] |Humans [MESH] |Kidney Transplantation/*adverse effects [MESH] |Male [MESH] |Middle Aged [MESH]Low proportion of follicular regulatory T cell in renal transplant pat(epmc).pdf DeepDyve Pubget Overpricing