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10.1038/s41598-017-01450-8 http://scihub22266oqcxt.onion/10.1038/s41598-017-01450-8 C5431002!5431002!28465556     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2017 ; 7 (ä): ä Nephropedia Template TP {{tp|p=28465556|t=2017. Control of in vivo ictogenesis via endogenous synaptic pathways |pdf=|usr=}}{{28465556}} gab.com Text Control of in vivo ictogenesis via endogenous synaptic pathways JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28465556 #FOAvip The random nature of seizures poses difficult challenges for epilepsy research. There is great need for a reliable method to control the pathway to seizure onset, which would allow investigation of the mechanisms of ictogenesis and optimization of treatments. Our hypothesis is that increased random afferent synaptic activity (i.e. synaptic noise) within the epileptic focus is one endogenous method of ictogenesis. Building upon previous theoretical and in vitro work showing that synaptic noise can induce seizures, we developed a novel in vivo model of ictogenesis. By increasing the excitability of afferent connections to the hippocampus, we control the risk of temporal lobe seizures during a specific time period. The afferent synaptic activity in the hippocampus was modulated by focal microinjections of potassium chloride into the nucleus reuniens, during which the risk of seizure occurrence increased substantially. The induced seizures were qualitatively and quantitatively indistinguishable from spontaneous ones. This model thus allows direct control of the temporal lobe seizure threshold via endogenous pathways, providing a novel tool in which to investigate the mechanisms and biomarkers of ictogenesis, test for seizure threshold, and rapidly tune antiseizure treatments. Twit Text FOAVip Control of in vivo ictogenesis via endogenous synaptic pathways ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28465556 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28465556 #FOAvip English Wikipedia <ref>{{Cite pmid|28465556}}</ref> Control of in vivo ictogenesis via endogenous synaptic pathways #MMPMID28465556 Luna-Munguia H; Starski P; Chen W; Gliske S; Stacey WC Sci Rep 2017[]; 7 (ä): ä PMID28465556show ga The random nature of seizures poses difficult challenges for epilepsy research. There is great need for a reliable method to control the pathway to seizure onset, which would allow investigation of the mechanisms of ictogenesis and optimization of treatments. Our hypothesis is that increased random afferent synaptic activity (i.e. synaptic noise) within the epileptic focus is one endogenous method of ictogenesis. Building upon previous theoretical and in vitro work showing that synaptic noise can induce seizures, we developed a novel in vivo model of ictogenesis. By increasing the excitability of afferent connections to the hippocampus, we control the risk of temporal lobe seizures during a specific time period. The afferent synaptic activity in the hippocampus was modulated by focal microinjections of potassium chloride into the nucleus reuniens, during which the risk of seizure occurrence increased substantially. The induced seizures were qualitatively and quantitatively indistinguishable from spontaneous ones. This model thus allows direct control of the temporal lobe seizure threshold via endogenous pathways, providing a novel tool in which to investigate the mechanisms and biomarkers of ictogenesis, test for seizure threshold, and rapidly tune antiseizure treatments. äControl of in vivo ictogenesis via endogenous synaptic pathways (epmc).pdf DeepDyve Pubget Overpricing