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10.1038/s41598-017-01404-0 http://scihub22266oqcxt.onion/10.1038/s41598-017-01404-0 C5430961!5430961!28465620     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2017 ; 7 (ä): ä Nephropedia Template TP {{tp|p=28465620|t=2017. IVIG regulates the survival of human but not mouse neutrophils |pdf=|usr=}}{{28465620}} gab.com Text IVIG regulates the survival of human but not mouse neutrophils JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28465620 #FOAvip Intravenous immunoglobulin (IVIG) are purified IgG preparations made from the pooled plasma from thousands of healthy donors and are being tested in preclinical mouse models. Inherent challenges, however, are the pluripotency of IVIG and its xenogeneicity in animals. IVIG can alter the viability of human neutrophils via agonistic antibodies to Fas and Siglec-9. In this study, we compared the effects of IVIG on human and mouse neutrophils using different death assays. Different commercial IVIG preparations similarly induced cytokine-dependent death in human neutrophils, whereas they had no effects on the survival of either peripheral blood or bone marrow neutrophils from C57BL/6 or BALB/c mice. F(ab?)2 but not Fc fragments of IVIG induced death of human neutrophils, whereas neither of these IVIG fragments, nor agonistic monoclonal antibodies to human Fas or Siglec-9 affected the viability of mouse neutrophils. Pooled mouse IgG, which exhibited a different immunoprofile compared to IVIG, also had no effect on mouse cells. Together, these observations demonstrate that effects of IVIG on neutrophil survival are not adequately reflected in current mouse models, despite the key role of these cells in human inflammatory and autoimmune diseases. Twit Text FOAVip IVIG regulates the survival of human but not mouse neutrophils ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28465620 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28465620 #FOAvip English Wikipedia <ref>{{Cite pmid|28465620}}</ref> IVIG regulates the survival of human but not mouse neutrophils #MMPMID28465620 Schneider C; Wicki S; Graeter S; Timcheva TM; Keller CW; Quast I; Leontyev D; Djoumerska-Alexieva IK; Käsermann F; Jakob SM; Dimitrova PA; Branch DR; Cummings RD; Lünemann JD; Kaufmann T; Simon HU; von Gunten S Sci Rep 2017[]; 7 (ä): ä PMID28465620show ga Intravenous immunoglobulin (IVIG) are purified IgG preparations made from the pooled plasma from thousands of healthy donors and are being tested in preclinical mouse models. Inherent challenges, however, are the pluripotency of IVIG and its xenogeneicity in animals. IVIG can alter the viability of human neutrophils via agonistic antibodies to Fas and Siglec-9. In this study, we compared the effects of IVIG on human and mouse neutrophils using different death assays. Different commercial IVIG preparations similarly induced cytokine-dependent death in human neutrophils, whereas they had no effects on the survival of either peripheral blood or bone marrow neutrophils from C57BL/6 or BALB/c mice. F(ab?)2 but not Fc fragments of IVIG induced death of human neutrophils, whereas neither of these IVIG fragments, nor agonistic monoclonal antibodies to human Fas or Siglec-9 affected the viability of mouse neutrophils. Pooled mouse IgG, which exhibited a different immunoprofile compared to IVIG, also had no effect on mouse cells. Together, these observations demonstrate that effects of IVIG on neutrophil survival are not adequately reflected in current mouse models, despite the key role of these cells in human inflammatory and autoimmune diseases. äIVIG regulates the survival of human but not mouse neutrophils (epmc).pdf DeepDyve Pubget Overpricing