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10.1038/s41598-017-01146-z http://scihub22266oqcxt.onion/10.1038/s41598-017-01146-z C5430913!5430913!28432359     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2017 ; 7 (ä): ä Nephropedia Template TP {{tp|p=28432359|t=2017. Role of the Ion Channel Extracellular Collar in AMPA Receptor Gating |pdf=|usr=}}{{28432359}} gab.com Text Role of the Ion Channel Extracellular Collar in AMPA Receptor Gating JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28432359 #FOAvip AMPA subtype ionotropic glutamate receptors mediate fast excitatory neurotransmission and are implicated in numerous neurological diseases. Ionic currents through AMPA receptor channels can be allosterically regulated via different sites on the receptor protein. We used site-directed mutagenesis and patch-clamp recordings to probe the ion channel extracellular collar, the binding region for noncompetitive allosteric inhibitors. We found position and substitution-dependent effects for introduced mutations at this region on AMPA receptor gating. The results of mutagenesis suggested that the transmembrane domains M1, M3 and M4, which contribute to the ion channel extracellular collar, undergo significant relative displacement during gating. We used molecular dynamics simulations to predict an AMPA receptor open state structure and rationalize the results of mutagenesis. We conclude that the ion channel extracellular collar plays a distinct role in gating and represents a hub for powerful allosteric modulation of AMPA receptor function that can be used for developing novel therapeutics. Twit Text FOAVip Role of the Ion Channel Extracellular Collar in AMPA Receptor Gating ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28432359 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28432359 #FOAvip English Wikipedia <ref>{{Cite pmid|28432359}}</ref> Role of the Ion Channel Extracellular Collar in AMPA Receptor Gating #MMPMID28432359 Yelshanskaya MV; Mesbahi-Vasey S; Kurnikova MG; Sobolevsky AI Sci Rep 2017[]; 7 (ä): ä PMID28432359show ga AMPA subtype ionotropic glutamate receptors mediate fast excitatory neurotransmission and are implicated in numerous neurological diseases. Ionic currents through AMPA receptor channels can be allosterically regulated via different sites on the receptor protein. We used site-directed mutagenesis and patch-clamp recordings to probe the ion channel extracellular collar, the binding region for noncompetitive allosteric inhibitors. We found position and substitution-dependent effects for introduced mutations at this region on AMPA receptor gating. The results of mutagenesis suggested that the transmembrane domains M1, M3 and M4, which contribute to the ion channel extracellular collar, undergo significant relative displacement during gating. We used molecular dynamics simulations to predict an AMPA receptor open state structure and rationalize the results of mutagenesis. We conclude that the ion channel extracellular collar plays a distinct role in gating and represents a hub for powerful allosteric modulation of AMPA receptor function that can be used for developing novel therapeutics. äRole of the Ion Channel Extracellular Collar in AMPA Receptor Gating (epmc).pdf DeepDyve Pubget Overpricing