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10.1038/s41598-017-01223-3

http://scihub22266oqcxt.onion/10.1038/s41598-017-01223-3
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suck abstract from ncbi


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pmid28439112      Sci+Rep 2017 ; 7 (ä): ä
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  • Tubular atrophy/interstitial fibrosis scores of Oxford classification combinded with proteinuria level at biopsy provides earlier risk prediction in lgA nephropathy #MMPMID28439112
  • Zhu X; Li H; Liu Y; You J; Qu Z; Yuan S; Peng Y; Liu F; Liu H
  • Sci Rep 2017[]; 7 (ä): ä PMID28439112show ga
  • The predictive effect of combining MEST with clinical data at biopsy on renal survival outcomes has not been investigated in patients with IgA nephropathy (IgAN). MEST of The Oxford classification of IgAN and 24-hour urine proteinuia measured at enrollment. The primary outcome was a composite of either ESRD (eGFR to <15?ml/min per 1.73?m2), or a permanent reduction in eGFR to below 50% of the value at biopsy. 742 patients were enrolled and follow-up >3 years, and were divided into two groups according to eGFR levels at biopsy. Multivariable logistical regression revealed that proteinuria at biopsy (OR 5.307 (95% Cl 3.003 to 9.376) p?=?0.000), tubular atrophy/interstitial fibrosis scores (T) in MEST (OR 3.915 (95%Cl 2.710 to 5.654) p?=?0.000) were the two predictors of eGFR decline for IgAN patients. Kaplan?Meier survival curves show significant difference in renal survival outcome among each T scores groups at biopsy (T0, T1, T2) (P?
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