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2017 ; 7
(1
): 1100
Nephropedia Template TP
gab.com Text
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Tubular atrophy/interstitial fibrosis scores of Oxford classification combinded
with proteinuria level at biopsy provides earlier risk prediction in lgA
nephropathy
#MMPMID28439112
Zhu X
; Li H
; Liu Y
; You J
; Qu Z
; Yuan S
; Peng Y
; Liu F
; Liu H
Sci Rep
2017[Apr]; 7
(1
): 1100
PMID28439112
show ga
The predictive effect of combining MEST with clinical data at biopsy on renal
survival outcomes has not been investigated in patients with IgA nephropathy
(IgAN). MEST of The Oxford classification of IgAN and 24-hour urine proteinuia
measured at enrollment. The primary outcome was a composite of either ESRD (eGFR
to <15?ml/min per 1.73?m(2)), or a permanent reduction in eGFR to below 50% of
the value at biopsy. 742 patients were enrolled and follow-up >3 years, and were
divided into two groups according to eGFR levels at biopsy. Multivariable
logistical regression revealed that proteinuria at biopsy (OR 5.307 (95% Cl 3.003
to 9.376) p?=?0.000), tubular atrophy/interstitial fibrosis scores (T) in MEST
(OR 3.915 (95%Cl 2.710 to 5.654) p?=?0.000) were the two predictors of eGFR
decline for IgAN patients. Kaplan-Meier survival curves show significant
difference in renal survival outcome among each T scores groups at biopsy (T0,
T1, T2) (P?0.05) and proteinuria levels at biopsy (P?0.05), individially.
Patients with T2 combined proteinuria at biopsy have the worst renal survival
outcome. In conclusion, T scores in MEST classification combined with proteinuria
at biopsy could be one of the important early predictors for the renal survial
outcomes in patients with IgAN.