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10.1038/s41598-017-01204-6

http://scihub22266oqcxt.onion/10.1038/s41598-017-01204-6
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C5430840!5430840!28432319
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suck abstract from ncbi


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pmid28432319      Sci+Rep 2017 ; 7 (ä): ä
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  • Diabetic Retinopathy and Clinical Parameters Favoring the Presence of Diabetic Nephropathy could Predict Renal Outcome in Patients with Diabetic Kidney Disease #MMPMID28432319
  • Hung CC; Lin HYH; Hwang DY; Kuo IC; Chiu YW; Lim LM; Hwang SJ; Chen HC
  • Sci Rep 2017[]; 7 (ä): ä PMID28432319show ga
  • Diabetes duration, diabetic retinopathy (DR), and a diagnostic model have been proposed as clinical parameters favoring the presence of diabetic nephropathy (DN) in biopsied patients with diabetic kidney disease. DN, compared with non-diabetic renal disease, had poorer renal outcomes. We tested whether these clinical parameters favoring DN are associated with poorer renal outcomes in non-biopsied patients. In this study, 1330 patients with type 2 diabetes and chronic kidney disease stages 1?4 were included and divided according to diabetes mellitus (DM) duration >8 years, DR, or a diagnostic model for DN. These clinical parameters favoring DN were found in 62?77% of patients and associated with higher levels of proteinuria. In a Cox survival analysis, DR and the diagnostic model favoring DN were associated with an increased risk for end-stage renal disease with adjusted hazard ratios of 1.69 (95% CI: 1.16?2.45, P?=?0.006) and 1.66 (95% CI: 1.05?2.61, P?=?0.029), respectively. DR was associated with an increased risk for rapid renal disease progression. DM >8 years was not associated with renal outcome. Propensity score-matched analyses also showed similar results. In conclusion, DR and the diagnostic model favoring DN were associated with poorer renal outcomes.
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