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2017 ; 7
(1
): 1236
Nephropedia Template TP
gab.com Text
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English Wikipedia
Diabetic Retinopathy and Clinical Parameters Favoring the Presence of Diabetic
Nephropathy could Predict Renal Outcome in Patients with Diabetic Kidney Disease
#MMPMID28432319
Hung CC
; Lin HY
; Hwang DY
; Kuo IC
; Chiu YW
; Lim LM
; Hwang SJ
; Chen HC
Sci Rep
2017[Apr]; 7
(1
): 1236
PMID28432319
show ga
Diabetes duration, diabetic retinopathy (DR), and a diagnostic model have been
proposed as clinical parameters favoring the presence of diabetic nephropathy
(DN) in biopsied patients with diabetic kidney disease. DN, compared with
non-diabetic renal disease, had poorer renal outcomes. We tested whether these
clinical parameters favoring DN are associated with poorer renal outcomes in
non-biopsied patients. In this study, 1330 patients with type 2 diabetes and
chronic kidney disease stages 1-4 were included and divided according to diabetes
mellitus (DM) duration >8 years, DR, or a diagnostic model for DN. These clinical
parameters favoring DN were found in 62-77% of patients and associated with
higher levels of proteinuria. In a Cox survival analysis, DR and the diagnostic
model favoring DN were associated with an increased risk for end-stage renal
disease with adjusted hazard ratios of 1.69 (95% CI: 1.16-2.45, P?=?0.006) and
1.66 (95% CI: 1.05-2.61, P?=?0.029), respectively. DR was associated with an
increased risk for rapid renal disease progression. DM >8 years was not
associated with renal outcome. Propensity score-matched analyses also showed
similar results. In conclusion, DR and the diagnostic model favoring DN were
associated with poorer renal outcomes.