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10.1038/s41598-017-01204-6

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suck abstract from ncbi


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pmid28432319
      Sci+Rep 2017 ; 7 (1 ): 1236
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  • Diabetic Retinopathy and Clinical Parameters Favoring the Presence of Diabetic Nephropathy could Predict Renal Outcome in Patients with Diabetic Kidney Disease #MMPMID28432319
  • Hung CC ; Lin HY ; Hwang DY ; Kuo IC ; Chiu YW ; Lim LM ; Hwang SJ ; Chen HC
  • Sci Rep 2017[Apr]; 7 (1 ): 1236 PMID28432319 show ga
  • Diabetes duration, diabetic retinopathy (DR), and a diagnostic model have been proposed as clinical parameters favoring the presence of diabetic nephropathy (DN) in biopsied patients with diabetic kidney disease. DN, compared with non-diabetic renal disease, had poorer renal outcomes. We tested whether these clinical parameters favoring DN are associated with poorer renal outcomes in non-biopsied patients. In this study, 1330 patients with type 2 diabetes and chronic kidney disease stages 1-4 were included and divided according to diabetes mellitus (DM) duration >8 years, DR, or a diagnostic model for DN. These clinical parameters favoring DN were found in 62-77% of patients and associated with higher levels of proteinuria. In a Cox survival analysis, DR and the diagnostic model favoring DN were associated with an increased risk for end-stage renal disease with adjusted hazard ratios of 1.69 (95% CI: 1.16-2.45, P?=?0.006) and 1.66 (95% CI: 1.05-2.61, P?=?0.029), respectively. DR was associated with an increased risk for rapid renal disease progression. DM >8 years was not associated with renal outcome. Propensity score-matched analyses also showed similar results. In conclusion, DR and the diagnostic model favoring DN were associated with poorer renal outcomes.
  • |Aged [MESH]
  • |Diabetic Nephropathies/complications/*diagnosis [MESH]
  • |Diabetic Retinopathy/complications/*diagnosis [MESH]
  • |Female [MESH]
  • |Glomerular Filtration Rate [MESH]
  • |Humans [MESH]
  • |Kidney Failure, Chronic/complications/diagnosis [MESH]
  • |Male [MESH]
  • |Middle Aged [MESH]
  • |Prognosis [MESH]
  • |Proteinuria/diagnosis/etiology [MESH]


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