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10.1038/s41598-017-00691-x http://scihub22266oqcxt.onion/10.1038/s41598-017-00691-x C5430717!5430717!28432285     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2017 ; 7 (ä): ä Nephropedia Template TP {{tp|p=28432285|t=2017. NOD1 modulates IL-10 signalling in human dendritic cells |pdf=|usr=}}{{28432285}} gab.com Text NOD1 modulates IL-10 signalling in human dendritic cells JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28432285 #FOAvip NOD1 belongs to the family of NOD-like receptors, which is a group of well-characterised, cytosolic pattern-recognition receptors. The best-studied function of NOD-like receptors is their role in generating immediate pro-inflammatory and antimicrobial responses by detecting specific bacterial peptidoglycans or by responding to cellular stress and danger-associated molecules. The present study describes a regulatory, peptidoglycan-independent function of NOD1 in anti-inflammatory immune responses. We report that, in human dendritic cells, NOD1 balances IL-10-induced STAT1 and STAT3 activation by a SOCS2-dependent mechanism, thereby suppressing the tolerogenic dendritic cell phenotype. Based on these findings, we propose that NOD1 contributes to inflammation not only by promoting pro-inflammatory processes, but also by suppressing anti-inflammatory pathways. Twit Text FOAVip NOD1 modulates IL-10 signalling in human dendritic cells ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28432285 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28432285 #FOAvip English Wikipedia <ref>{{Cite pmid|28432285}}</ref> NOD1 modulates IL-10 signalling in human dendritic cells #MMPMID28432285 Neuper T; Ellwanger K; Schwarz H; Kufer TA; Duschl A; Horejs-Hoeck J Sci Rep 2017[]; 7 (ä): ä PMID28432285show ga NOD1 belongs to the family of NOD-like receptors, which is a group of well-characterised, cytosolic pattern-recognition receptors. The best-studied function of NOD-like receptors is their role in generating immediate pro-inflammatory and antimicrobial responses by detecting specific bacterial peptidoglycans or by responding to cellular stress and danger-associated molecules. The present study describes a regulatory, peptidoglycan-independent function of NOD1 in anti-inflammatory immune responses. We report that, in human dendritic cells, NOD1 balances IL-10-induced STAT1 and STAT3 activation by a SOCS2-dependent mechanism, thereby suppressing the tolerogenic dendritic cell phenotype. Based on these findings, we propose that NOD1 contributes to inflammation not only by promoting pro-inflammatory processes, but also by suppressing anti-inflammatory pathways. äNOD1 modulates IL-10 signalling in human dendritic cells (epmc).pdf DeepDyve Pubget Overpricing