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10.1021/acsmedchemlett.6b00468

http://scihub22266oqcxt.onion/10.1021/acsmedchemlett.6b00468
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C5430396!5430396!28523099
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suck abstract from ncbi


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pmid28523099      ACS+Med+Chem+Lett 2017 ; 8 (5): 492-7
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  • Identification of New FLT3 Inhibitors That Potently Inhibit AML Cell Lines via an Azo Click-It/Staple-It Approach #MMPMID28523099
  • Ma X; Zhou J; Wang C; Carter-Cooper B; Yang F; Larocque E; Fine J; Tsuji G; Chopra G; Lapidus RG; Sintim HO
  • ACS Med Chem Lett 2017[May]; 8 (5): 492-7 PMID28523099show ga
  • Acute myeloid leukemia (AML) is an aggressive malignancy with only a handful of therapeutic options. About 30% of AML patients harbor mutated FLT3 kinase, and thus, this cancer-driver has become a hotly pursued AML target. Herein we report a new class of FLT3 inhibitors, which potently inhibit the proliferation of acute myeloid leukemia (AML) cells at nanomolar concentrations.
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