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10.1021/acsmedchemlett.7b00157 http://scihub22266oqcxt.onion/10.1021/acsmedchemlett.7b00157 C5430394!5430394!28523115     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       ACS+Med+Chem+Lett 2017 ; 8 (5): 582-6 Nephropedia Template TP {{tp|p=28523115|t=2017. Discovery of Fevipiprant (NVP-QAW039), a Potent and Selective DP2 Receptor Antagonist for Treatment of Asthma |pdf=|usr=}}{{28523115}} gab.com Text Discovery of Fevipiprant (NVP-QAW039), a Potent and Selective DP2 Receptor Antagonist for Treatment of Asthma JO: ACS Med Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=28523115 #FOAvip Further optimization of an initial DP2 receptor antagonist clinical candidate NVP-QAV680 led to the discovery of a follow-up molecule 2-(2-methyl-1-(4-(methylsulfonyl)-2-(trifluoromethyl)benzyl)-1H-pyrrolo[2,3-b]pyr idin-3-yl)acetic acid (compound 11, NVP-QAW039, fevipiprant), which exhibits improved potency on human eosinophils and Th2 cells, together with a longer receptor residence time, and is currently in clinical trials for severe asthma. Twit Text FOAVip Discovery of Fevipiprant (NVP-QAW039), a Potent and Selective DP2 Receptor Antagonist for Treatment of Asthma ????ACS Med Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=28523115 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28523115 #FOAvip English Wikipedia <ref>{{Cite pmid|28523115}}</ref> Discovery of Fevipiprant (NVP-QAW039), a Potent and Selective DP2 Receptor Antagonist for Treatment of Asthma #MMPMID28523115 Sandham DA; Barker L; Brown L; Brown Z; Budd D; Charlton SJ; Chatterjee D; Cox B; Dubois G; Duggan N; Hall E; Hatto J; Maas J; Manini J; Profit R; Riddy D; Ritchie C; Sohal B; Shaw D; Stringer R; Sykes DA; Thomas M; Turner KL; Watson SJ; West R; Willard E; Williams G; Willis J ACS Med Chem Lett 2017[May]; 8 (5): 582-6 PMID28523115show ga Further optimization of an initial DP2 receptor antagonist clinical candidate NVP-QAV680 led to the discovery of a follow-up molecule 2-(2-methyl-1-(4-(methylsulfonyl)-2-(trifluoromethyl)benzyl)-1H-pyrrolo[2,3-b]pyr idin-3-yl)acetic acid (compound 11, NVP-QAW039, fevipiprant), which exhibits improved potency on human eosinophils and Th2 cells, together with a longer receptor residence time, and is currently in clinical trials for severe asthma. äDiscovery of Fevipiprant (NVP-QAW039), a Potent and Selective DP2 Rece(epmc).pdf DeepDyve Pubget Overpricing