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10.1021/acsmedchemlett.7b00157 http://scihub22266oqcxt.onion/10.1021/acsmedchemlett.7b00157 C5430394!5430394 !28523115     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28523115 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28523115 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       ACS+Med+Chem+Lett 2017 ; 8 (5 ): 582-586 Nephropedia Template TP {{tp|p=28523115 |t=2017. Discovery of Fevipiprant (NVP-QAW039), a Potent and Selective DP(2) Receptor Antagonist for Treatment of Asthma |pdf=|usr=}}{{28523115 }} gab.com Text Discovery of Fevipiprant (NVP-QAW039), a Potent and Selective DP(2) Receptor Antagonist for Treatment of Asthma JO: ACS Med Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=28523115 #FOAvip Further optimization of an initial DP(2) receptor antagonist clinical candidate NVP-QAV680 led to the discovery of a follow-up molecule 2-(2-methyl-1-(4-(methylsulfonyl)-2-(trifluoromethyl)benzyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)acetic acid (compound 11, NVP-QAW039, fevipiprant), which exhibits improved potency on human eosinophils and Th2 cells, together with a longer receptor residence time, and is currently in clinical trials for severe asthma. Twit Text FOAVip Discovery of Fevipiprant (NVP-QAW039), a Potent and Selective DP(2) Receptor Antagonist for Treatment of Asthma ????ACS Med Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=28523115 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28523115 #FOAvip English Wikipedia <ref>{{Cite pmid|28523115 }}</ref> Discovery of Fevipiprant (NVP-QAW039), a Potent and Selective DP(2) Receptor Antagonist for Treatment of Asthma #MMPMID28523115 Sandham DA ; Barker L ; Brown L ; Brown Z ; Budd D ; Charlton SJ ; Chatterjee D ; Cox B ; Dubois G ; Duggan N ; Hall E ; Hatto J ; Maas J ; Manini J ; Profit R ; Riddy D ; Ritchie C ; Sohal B ; Shaw D ; Stringer R ; Sykes DA ; Thomas M ; Turner KL ; Watson SJ ; West R ; Willard E ; Williams G ; Willis J ACS Med Chem Lett 2017[May]; 8 (5 ): 582-586 PMID28523115 show ga Further optimization of an initial DP(2) receptor antagonist clinical candidate NVP-QAV680 led to the discovery of a follow-up molecule 2-(2-methyl-1-(4-(methylsulfonyl)-2-(trifluoromethyl)benzyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)acetic acid (compound 11, NVP-QAW039, fevipiprant), which exhibits improved potency on human eosinophils and Th2 cells, together with a longer receptor residence time, and is currently in clinical trials for severe asthma. äDiscovery of Fevipiprant (NVP-QAW039), a Potent and Selective DP(2) Re(epmc).pdf DeepDyve Pubget Overpricing