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10.1007/s12551-016-0223-9 http://scihub22266oqcxt.onion/10.1007/s12551-016-0223-9 C5430296!5430296!28510023     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biophys+Rev 2016 ; 8 (4): 359-67 Nephropedia Template TP {{tp|p=28510023|t=2016. Protein?RNA interactions: structural biology and computational modeling techniques |pdf=|usr=}}{{28510023}} gab.com Text Protein RNA interactions: structural biology and computational modeling techniques JO: Biophys Rev http://www.kidney.de/pget.php?&tw=1&pmid=28510023 #FOAvip RNA-binding proteins are functionally diverse within cells, being involved in RNA-metabolism, translation, DNA damage repair, and gene regulation at both the transcriptional and post-transcriptional levels. Much has been learnt about their interactions with RNAs through structure determination techniques and computational modeling. This review gives an overview of the structural data currently available for protein?RNA complexes, and discusses the technical issues facing structural biologists working to solve their structures. The review focuses on three techniques used to solve the 3-dimensional structure of protein?RNA complexes at atomic resolution, namely X-ray crystallography, solution nuclear magnetic resonance (NMR) and cryo-electron microscopy (cryo-EM). The review then focuses on the main computational modeling techniques that use these atomic resolution data: discussing the prediction of RNA-binding sites on unbound proteins, docking proteins, and RNAs, and modeling the molecular dynamics of the systems. In conclusion, the review looks at the future directions this field of research might take. Twit Text FOAVip Protein RNA interactions: structural biology and computational modeling techniques ????Biophys Rev http://www.kidney.de/pget.php?&tw=1&pmid=28510023 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28510023 #FOAvip English Wikipedia <ref>{{Cite pmid|28510023}}</ref> Protein?RNA interactions: structural biology and computational modeling techniques #MMPMID28510023 Jones S Biophys Rev 2016[Dec]; 8 (4): 359-67 PMID28510023show ga RNA-binding proteins are functionally diverse within cells, being involved in RNA-metabolism, translation, DNA damage repair, and gene regulation at both the transcriptional and post-transcriptional levels. Much has been learnt about their interactions with RNAs through structure determination techniques and computational modeling. This review gives an overview of the structural data currently available for protein?RNA complexes, and discusses the technical issues facing structural biologists working to solve their structures. The review focuses on three techniques used to solve the 3-dimensional structure of protein?RNA complexes at atomic resolution, namely X-ray crystallography, solution nuclear magnetic resonance (NMR) and cryo-electron microscopy (cryo-EM). The review then focuses on the main computational modeling techniques that use these atomic resolution data: discussing the prediction of RNA-binding sites on unbound proteins, docking proteins, and RNAs, and modeling the molecular dynamics of the systems. In conclusion, the review looks at the future directions this field of research might take. äProtein?RNA interactions: structural biology and computational modelin(epmc).pdf DeepDyve Pubget Overpricing