Intracellular calcium release channels: an update #MMPMID28303572
Santulli G; Nakashima R; Yuan Q; Marks AR
J Physiol 2017[May]; 595 (10): 3041-51 PMID28303572show ga
Ryanodine receptors (RyRs) and inositol 1,4,5?trisphosphate receptors (IP3Rs) are calcium (Ca2+) release channels on the endo/sarcoplasmic reticulum (ER/SR). Here we summarize the latest advances in the field, describing the recently discovered mechanistic roles of intracellular Ca2+ release channels in the regulation of mitochondrial fitness and endothelial function, providing novel therapeutic options for the treatment of heart failure, hypertension, and diabetes mellitus.