Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.14814/phy2.13283 http://scihub22266oqcxt.onion/10.14814/phy2.13283 C5430128!5430128!28507167     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Physiol+Rep 2017 ; 5 (9): ä Nephropedia Template TP {{tp|p=28507167|t=2017. Early activation of deleterious molecular pathways in the kidney in experimental heart failure with atrial remodeling |pdf=|usr=}}{{28507167}} gab.com Text Early activation of deleterious molecular pathways in the kidney in experimental heart failure with atrial remodeling JO: Physiol Rep http://www.kidney.de/pget.php?&tw=1&pmid=28507167 #FOAvip Heart failure (HF) is a major health problem with worsening outcomes when renal impairment is present. Therapeutics for early phase HF may be effective for cardiorenal protection, however the detailed characteristics of the kidney in early?stage HF (ES?HF), and therefore treatment for potential renal protection, are poorly defined. We sought to determine the gene and protein expression profiles of specific maladaptive pathways of ES?HF in the kidney and heart. Experimental canine ES?HF, characterized by de?novo HF with atrial remodeling but not ventricular fibrosis, was induced by right ventricular pacing for 10 days. Kidney cortex (KC), medulla (KM), left ventricle (LV), and left atrial (LA) tissues from ES?HF versus normal canines (n = 4 of each) were analyzed using RT?PCR microarrays and protein assays to assess genes and proteins related to inflammation, renal injury, apoptosis, and fibrosis. ES?HF was characterized by increased circulating natriuretic peptides and components of the renin?angiotensin?aldosterone system and decreased sodium and water excretion with mild renal injury and up?regulation of CNP and renin genes in the kidney. Compared to normals, widespread genes, especially genes of the inflammatory pathways, were up?regulated in KC similar to increases seen in LA. Protein expressions related to inflammatory cytokines were also augmented in the KC. Gene and protein changes were less prominent in the LV and KM. The ES?HF displayed mild renal injury with widespread gene changes and increased inflammatory cytokines. These changes may provide important clues into the pathophysiology of ES?HF and for therapeutic molecular targets in the kidney of ES?HF. Twit Text FOAVip Early activation of deleterious molecular pathways in the kidney in experimental heart failure with atrial remodeling ????Physiol Rep http://www.kidney.de/pget.php?&tw=1&pmid=28507167 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28507167 #FOAvip English Wikipedia <ref>{{Cite pmid|28507167}}</ref> Early activation of deleterious molecular pathways in the kidney in experimental heart failure with atrial remodeling #MMPMID28507167 Ichiki T; Huntley BK; Harty GJ; Sangaralingham SJ; Burnett JC Physiol Rep 2017[May]; 5 (9): ä PMID28507167show ga Heart failure (HF) is a major health problem with worsening outcomes when renal impairment is present. Therapeutics for early phase HF may be effective for cardiorenal protection, however the detailed characteristics of the kidney in early?stage HF (ES?HF), and therefore treatment for potential renal protection, are poorly defined. We sought to determine the gene and protein expression profiles of specific maladaptive pathways of ES?HF in the kidney and heart. Experimental canine ES?HF, characterized by de?novo HF with atrial remodeling but not ventricular fibrosis, was induced by right ventricular pacing for 10 days. Kidney cortex (KC), medulla (KM), left ventricle (LV), and left atrial (LA) tissues from ES?HF versus normal canines (n = 4 of each) were analyzed using RT?PCR microarrays and protein assays to assess genes and proteins related to inflammation, renal injury, apoptosis, and fibrosis. ES?HF was characterized by increased circulating natriuretic peptides and components of the renin?angiotensin?aldosterone system and decreased sodium and water excretion with mild renal injury and up?regulation of CNP and renin genes in the kidney. Compared to normals, widespread genes, especially genes of the inflammatory pathways, were up?regulated in KC similar to increases seen in LA. Protein expressions related to inflammatory cytokines were also augmented in the KC. Gene and protein changes were less prominent in the LV and KM. The ES?HF displayed mild renal injury with widespread gene changes and increased inflammatory cytokines. These changes may provide important clues into the pathophysiology of ES?HF and for therapeutic molecular targets in the kidney of ES?HF. äEarly activation of deleterious molecular pathways in the kidney in ex(epmc).pdf DeepDyve Pubget Overpricing