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2017 ; 15
(2
): 203-207
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Red flag symptoms: detailed account of clinicopathological features in
young-onset colorectal cancer
#MMPMID28522950
Riaz R
; Masood N
; Benish A
Intest Res
2017[Apr]; 15
(2
): 203-207
PMID28522950
show ga
BACKGROUND/AIMS: Colorectal cancer has long been considered disease of the West,
typically occurring in old age; however, the incidence is rising in Asia. The
pattern of disease is quite different in Asia, occurring at a younger age and at
an advanced stage. Recognition of disease at an early stage is still a challenge
for physicians. Few data are available regarding young-onset colorectal cancer in
Pakistan. We conducted this study to fill this gap and provide deeper insight
into clinical symptoms and histopathological features of young-onset colorectal
cancer. METHODS: We collected data regarding clinical features by directly
interviewing patients and obtaining histopathological data from hospital records.
Patients aged less than 50 years were included in the study. Statistical analysis
was performed using IBM SPSS version 20.0. RESULTS: Results in 105 patients
showed mean age at diagnosis was 35.90±9.39, with male predominance; the majority
of patients had no family history of colorectal cancer. Most patients had
left-sided tumors with advance stage and intermediate grade (grade 2). Mucinous
histology was common. Rectal bleeding was the first symptom for left-sided
tumors, whereas most of the right-sided lesions presented with sudden
obstruction. CONCLUSIONS: Painless rectal bleeding in the early thirties should
alert physicians to advise appropriate investigation, as the majority of
young-onset colorectal cancer patients develop painless bleeding 2 to 3 years
before appearance of other symptoms.