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10.1016/j.drudis.2016.12.003 http://scihub22266oqcxt.onion/10.1016/j.drudis.2016.12.003 C5429979!5429979!27988359     free     free     free       Drug+Discov+Today 2017 ; 22 (5): 796-804 Nephropedia Template TP {{tp|p=27988359|t=2017. Targeting amino acid metabolism for cancer therapy |pdf=|usr=}}{{27988359}} gab.com Text Targeting amino acid metabolism for cancer therapy JO: Drug Discov Today http://www.kidney.de/pget.php?&tw=1&pmid=27988359 #FOAvip To support sustained biomass accumulation, tumor cells undergo metabolic reprogramming. Nutrient transporters and metabolic enzymes are regulated by the same oncogenic signals that drive cell-cycle progression. Some of the earliest cancer therapies used antimetabolites to disrupt tumor metabolism, and there is now renewed interest in developing drugs that target metabolic dependencies. Many cancers exhibit increased demand for specific amino acids, and become dependent on either an exogenous supply or upregulated de novo synthesis. Strategies to exploit such ?metabolic addictions? include depleting amino acids in blood serum, blocking uptake by transporters and inhibiting biosynthetic or catabolic enzymes. Recent findings highlight the importance of using appropriate model systems and identifying target patient groups as potential therapies advance into the clinic. Twit Text FOAVip Targeting amino acid metabolism for cancer therapy ????Drug Discov Today http://www.kidney.de/pget.php?&tw=1&pmid=27988359 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27988359 #FOAvip English Wikipedia <ref>{{Cite pmid|27988359}}</ref> Targeting amino acid metabolism for cancer therapy #MMPMID27988359 Lukey MJ; Katt WP; Cerione RA Drug Discov Today 2017[May]; 22 (5): 796-804 PMID27988359show ga To support sustained biomass accumulation, tumor cells undergo metabolic reprogramming. Nutrient transporters and metabolic enzymes are regulated by the same oncogenic signals that drive cell-cycle progression. Some of the earliest cancer therapies used antimetabolites to disrupt tumor metabolism, and there is now renewed interest in developing drugs that target metabolic dependencies. Many cancers exhibit increased demand for specific amino acids, and become dependent on either an exogenous supply or upregulated de novo synthesis. Strategies to exploit such ?metabolic addictions? include depleting amino acids in blood serum, blocking uptake by transporters and inhibiting biosynthetic or catabolic enzymes. Recent findings highlight the importance of using appropriate model systems and identifying target patient groups as potential therapies advance into the clinic. äTargeting amino acid metabolism for cancer therapy (epmc).pdf DeepDyve Pubget Overpricing