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10.1038/s41598-017-00842-0 http://scihub22266oqcxt.onion/10.1038/s41598-017-00842-0 C5429746!5429746!28400578     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2017 ; 7 (ä): ä Nephropedia Template TP {{tp|p=28400578|t=2017. Elevated levels of Wnt signaling disrupt thymus morphogenesis and function |pdf=|usr=}}{{28400578}} gab.com Text Elevated levels of Wnt signaling disrupt thymus morphogenesis and function JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28400578 #FOAvip All vertebrates possess a thymus, whose epithelial microenvironment is essential for T cell development and maturation. Despite the importance of the thymus for cellular immune defense, many questions surrounding its morphogenesis remain unanswered. Here, we demonstrate that, in contrast to the situation in many other epithelial cell types, differentiation of thymic epithelial cells (TECs) proceeds normally in the absence of canonical Wnt signaling and the classical adhesion molecule E-cadherin. By contrast, TEC-intrinsic activation of ?-catenin-dependent Wnt signaling blocks the morphogenesis of the thymus, and overexpression of a secreted Wnt ligand by TECs dominantly modifies the morphogenesis not only of the thymus, but also of the parathyroid and thyroid. These observations indicate that Wnt signaling activity in the thymus needs to be precisely controlled to support normal TEC differentiation, and suggest possible mechanisms underlying anatomical variations of the thymus, parathyroid and thyroid in humans. Twit Text FOAVip Elevated levels of Wnt signaling disrupt thymus morphogenesis and function ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28400578 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28400578 #FOAvip English Wikipedia <ref>{{Cite pmid|28400578}}</ref> Elevated levels of Wnt signaling disrupt thymus morphogenesis and function #MMPMID28400578 Swann JB; Happe C; Boehm T Sci Rep 2017[]; 7 (ä): ä PMID28400578show ga All vertebrates possess a thymus, whose epithelial microenvironment is essential for T cell development and maturation. Despite the importance of the thymus for cellular immune defense, many questions surrounding its morphogenesis remain unanswered. Here, we demonstrate that, in contrast to the situation in many other epithelial cell types, differentiation of thymic epithelial cells (TECs) proceeds normally in the absence of canonical Wnt signaling and the classical adhesion molecule E-cadherin. By contrast, TEC-intrinsic activation of ?-catenin-dependent Wnt signaling blocks the morphogenesis of the thymus, and overexpression of a secreted Wnt ligand by TECs dominantly modifies the morphogenesis not only of the thymus, but also of the parathyroid and thyroid. These observations indicate that Wnt signaling activity in the thymus needs to be precisely controlled to support normal TEC differentiation, and suggest possible mechanisms underlying anatomical variations of the thymus, parathyroid and thyroid in humans. äElevated levels of Wnt signaling disrupt thymus morphogenesis and func(epmc).pdf DeepDyve Pubget Overpricing