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10.1007/s00439-017-1786-7 http://scihub22266oqcxt.onion/10.1007/s00439-017-1786-7 C5429372!5429372!28374190     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Hum+Genet 2017 ; 136 (6): 727-41 Nephropedia Template TP {{tp|p=28374190|t=2017. A genome-wide study of Hardy?Weinberg equilibrium with next generation sequence data |pdf=|usr=}}{{28374190}} gab.com Text A genome-wide study of Hardy Weinberg equilibrium with next generation sequence data JO: Hum Genet http://www.kidney.de/pget.php?&tw=1&pmid=28374190 #FOAvip Statistical tests for Hardy?Weinberg equilibrium have been an important tool for detecting genotyping errors in the past, and remain important in the quality control of next generation sequence data. In this paper, we analyze complete chromosomes of the 1000 genomes project by using exact test procedures for autosomal and X-chromosomal variants. We find that the rate of disequilibrium largely exceeds what might be expected by chance alone for all chromosomes. Observed disequilibrium is, in about 60% of the cases, due to heterozygote excess. We suggest that most excess disequilibrium can be explained by sequencing problems, and hypothesize mechanisms that can explain exceptional heterozygosities. We report higher rates of disequilibrium for the MHC region on chromosome 6, regions flanking centromeres and p-arms of acrocentric chromosomes. We also detected long-range haplotypes and areas with incidental high disequilibrium. We report disequilibrium to be related to read depth, with variants having extreme read depths being more likely to be out of equilibrium. Disequilibrium rates were found to be 11 times higher in segmental duplications and simple tandem repeat regions. The variants with significant disequilibrium are seen to be concentrated in these areas. For next generation sequence data, Hardy?Weinberg disequilibrium seems to be a major indicator for copy number variation.Electronic supplementary material: The online version of this article (doi:10.1007/s00439-017-1786-7) contains supplementary material, which is available to authorized users. Twit Text FOAVip A genome-wide study of Hardy Weinberg equilibrium with next generation sequence data ????Hum Genet http://www.kidney.de/pget.php?&tw=1&pmid=28374190 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28374190 #FOAvip English Wikipedia <ref>{{Cite pmid|28374190}}</ref> A genome-wide study of Hardy?Weinberg equilibrium with next generation sequence data #MMPMID28374190 Graffelman J; Jain D; Weir B Hum Genet 2017[]; 136 (6): 727-41 PMID28374190show ga Statistical tests for Hardy?Weinberg equilibrium have been an important tool for detecting genotyping errors in the past, and remain important in the quality control of next generation sequence data. In this paper, we analyze complete chromosomes of the 1000 genomes project by using exact test procedures for autosomal and X-chromosomal variants. We find that the rate of disequilibrium largely exceeds what might be expected by chance alone for all chromosomes. Observed disequilibrium is, in about 60% of the cases, due to heterozygote excess. We suggest that most excess disequilibrium can be explained by sequencing problems, and hypothesize mechanisms that can explain exceptional heterozygosities. We report higher rates of disequilibrium for the MHC region on chromosome 6, regions flanking centromeres and p-arms of acrocentric chromosomes. We also detected long-range haplotypes and areas with incidental high disequilibrium. We report disequilibrium to be related to read depth, with variants having extreme read depths being more likely to be out of equilibrium. Disequilibrium rates were found to be 11 times higher in segmental duplications and simple tandem repeat regions. The variants with significant disequilibrium are seen to be concentrated in these areas. For next generation sequence data, Hardy?Weinberg disequilibrium seems to be a major indicator for copy number variation.Electronic supplementary material: The online version of this article (doi:10.1007/s00439-017-1786-7) contains supplementary material, which is available to authorized users. äA genome-wide study of Hardy?Weinberg equilibrium with next generation(epmc).pdf DeepDyve Pubget Overpricing