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10.1371/journal.pone.0176413 http://scihub22266oqcxt.onion/10.1371/journal.pone.0176413 C5428913!5428913!28498832     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+One 2017 ; 12 (5): ä Nephropedia Template TP {{tp|p=28498832|t=2017. Prenatal exposure to the Great Chinese Famine and mid-age hypertension |pdf=|usr=}}{{28498832}} gab.com Text Prenatal exposure to the Great Chinese Famine and mid-age hypertension JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=28498832 #FOAvip Background: One of the most terrible famines last century was Great Chinese Famine (GCF) in 1959~1961 when millions of people died from starving. Under-nutrition during famine between the Western and Eastern (Dutch Hungry vs. GCF) was similar, while cardiovascular consequences might not be the same. Addressing such questions may gain new insight into prevention of cardiovascular diseases. Methods: A retrospective cohort of 18,593 participants aged 43?49 years of old, was from Suzhou, China. Logistic regression model was used to calculate the relative risk (RR) of hypertension and corresponding 95% confidence interval (CI). The multivariate RRs were adjusted for age, plasma glucose, triglyceride, and cholesterol. Results: The multivariate RRs of systolic and diastolic pressure were not significantly elevated in the rural subgroups, but was higher in the urban population born in the famine (systolic pressure adjust RR 1.382, 95% CI 1.235?1.545, diastolic pressure adjust RR 1.569, 95% CI 1.415?1.740). The risks of hypertension were significantly higher among the urban subjects than that in the rural subgroups (systolic hypertension adjust RR 2.915, 95% CI 2.616?3.249, diastolic hypertension adjust RR 4.568, 95% CI 4.079?5.116). Percentile of optimal diastolic pressure at mid-age was significantly lower in the urban population prenatally exposed to the famine regardless of sexes. However, a similar reduction of percentage of optimal systolic pressure was only seen in the female, not the male population in the urban region. Conclusion: The data suggest Asian genetic basis was not able to block famine-programmed vascular diseases as that happened in Europe, and the programmed problems due to under-nutrition could be reversed after birth. Protective mechanisms may be related to diet habits before age of 30 years old, which is important contribution to early prevention of hypertension. Twit Text FOAVip Prenatal exposure to the Great Chinese Famine and mid-age hypertension ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=28498832 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28498832 #FOAvip English Wikipedia <ref>{{Cite pmid|28498832}}</ref> Prenatal exposure to the Great Chinese Famine and mid-age hypertension #MMPMID28498832 Wu L; Feng X; He A; Ding Y; Zhou X; Xu Z PLoS One 2017[]; 12 (5): ä PMID28498832show ga Background: One of the most terrible famines last century was Great Chinese Famine (GCF) in 1959~1961 when millions of people died from starving. Under-nutrition during famine between the Western and Eastern (Dutch Hungry vs. GCF) was similar, while cardiovascular consequences might not be the same. Addressing such questions may gain new insight into prevention of cardiovascular diseases. Methods: A retrospective cohort of 18,593 participants aged 43?49 years of old, was from Suzhou, China. Logistic regression model was used to calculate the relative risk (RR) of hypertension and corresponding 95% confidence interval (CI). The multivariate RRs were adjusted for age, plasma glucose, triglyceride, and cholesterol. Results: The multivariate RRs of systolic and diastolic pressure were not significantly elevated in the rural subgroups, but was higher in the urban population born in the famine (systolic pressure adjust RR 1.382, 95% CI 1.235?1.545, diastolic pressure adjust RR 1.569, 95% CI 1.415?1.740). The risks of hypertension were significantly higher among the urban subjects than that in the rural subgroups (systolic hypertension adjust RR 2.915, 95% CI 2.616?3.249, diastolic hypertension adjust RR 4.568, 95% CI 4.079?5.116). Percentile of optimal diastolic pressure at mid-age was significantly lower in the urban population prenatally exposed to the famine regardless of sexes. However, a similar reduction of percentage of optimal systolic pressure was only seen in the female, not the male population in the urban region. Conclusion: The data suggest Asian genetic basis was not able to block famine-programmed vascular diseases as that happened in Europe, and the programmed problems due to under-nutrition could be reversed after birth. Protective mechanisms may be related to diet habits before age of 30 years old, which is important contribution to early prevention of hypertension. äPrenatal exposure to the Great Chinese Famine and mid-age hypertension(epmc).pdf DeepDyve Pubget Overpricing