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10.1160/TH15-07-0541 http://scihub22266oqcxt.onion/10.1160/TH15-07-0541 C5428546!5428546!26763081     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Thromb+Haemost 2016 ; 115 (5): 1025-33 Nephropedia Template TP {{tp|p=26763081|t=2016. Tissue Factor associates with survival and regulates tumor progression in osteosarcoma |pdf=|usr=}}{{26763081}} gab.com Text Tissue Factor associates with survival and regulates tumor progression in osteosarcoma JO: Thromb Haemost http://www.kidney.de/pget.php?&tw=1&pmid=26763081 #FOAvip Osteosarcoma is the most common primary malignant bone tumor. Patients often develop lung metastasis and have a poor prognosis despite extensive chemotherapy and surgical resections. Tissue Factor is associated with poor clinical outcome in a wide range of cancer types, and promotes angiogenesis and metastasis. The role of Tissue Factor in OS tumorigenesis is unknown. 53 osteosarcoma pre-treatment biopsies and four osteosarcoma cell lines were evaluated for Tissue Factor expression, and a possible association with clinical parameters was investigated. Tissue Factor function was inhibited in an osteosarcoma cell line (143B) by shRNA knockdown or specific antibodies, and pro-tumorigenic gene expression, proliferation, matrigel invasion and transwell migration was examined. 143B cells were implanted in mice in the presence of Tissue Factor-blocking antibodies, and tumor volume, micro-vessel density and metastases in the lung were evaluated.Tissue Factor was highly expressed in 73.6% of osteosarcoma biopsies, and expression associated significantly with disease-free survival. Tissue Factor was expressed in all four investigated cell lines. Tissue Factor was knocked down in 143B cells, which led to reduced expression of IL-8, CXCL-1, SNAIL and MMP2, but not MMP9. Tissue Factor knockdown or inhibition with antibodies reduced matrigel invasion. Tissue Factor antibodies limited 143B tumor growth in vivo, and resulted in decreased intra-tumoral micro-vessel density. Furthermore, lung metastasis from the primary tumor was significantly reduced. Thus, Tissue Factor expression in osteosarcoma reduces metastasis-free survival in patients, and increases pro-tumorigenic behavior both in vitro and in vivo. Twit Text FOAVip Tissue Factor associates with survival and regulates tumor progression in osteosarcoma ????Thromb Haemost http://www.kidney.de/pget.php?&tw=1&pmid=26763081 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26763081 #FOAvip English Wikipedia <ref>{{Cite pmid|26763081}}</ref> Tissue Factor associates with survival and regulates tumor progression in osteosarcoma #MMPMID26763081 Tieken C; Verboom MC; Ruf W; Gelderblom H; Bovée JV; Reitsma PH; Cleton-Jansen AM; Versteeg HH Thromb Haemost 2016[May]; 115 (5): 1025-33 PMID26763081show ga Osteosarcoma is the most common primary malignant bone tumor. Patients often develop lung metastasis and have a poor prognosis despite extensive chemotherapy and surgical resections. Tissue Factor is associated with poor clinical outcome in a wide range of cancer types, and promotes angiogenesis and metastasis. The role of Tissue Factor in OS tumorigenesis is unknown. 53 osteosarcoma pre-treatment biopsies and four osteosarcoma cell lines were evaluated for Tissue Factor expression, and a possible association with clinical parameters was investigated. Tissue Factor function was inhibited in an osteosarcoma cell line (143B) by shRNA knockdown or specific antibodies, and pro-tumorigenic gene expression, proliferation, matrigel invasion and transwell migration was examined. 143B cells were implanted in mice in the presence of Tissue Factor-blocking antibodies, and tumor volume, micro-vessel density and metastases in the lung were evaluated.Tissue Factor was highly expressed in 73.6% of osteosarcoma biopsies, and expression associated significantly with disease-free survival. Tissue Factor was expressed in all four investigated cell lines. Tissue Factor was knocked down in 143B cells, which led to reduced expression of IL-8, CXCL-1, SNAIL and MMP2, but not MMP9. Tissue Factor knockdown or inhibition with antibodies reduced matrigel invasion. Tissue Factor antibodies limited 143B tumor growth in vivo, and resulted in decreased intra-tumoral micro-vessel density. Furthermore, lung metastasis from the primary tumor was significantly reduced. Thus, Tissue Factor expression in osteosarcoma reduces metastasis-free survival in patients, and increases pro-tumorigenic behavior both in vitro and in vivo. äTissue Factor associates with survival and regulates tumor progression(epmc).pdf DeepDyve Pubget Overpricing